Protein profile

PA3393

copper-binding periplasmic protein

Genome: NC_002516.2

Gene: nosD PA3393 Structure source: AlphaFold UniProt Q9HYL1
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Amino acids 428
Annotations 1
Features 40
PDB binders 0
Druggability 0.511

Overview

Basic information about this protein and its source genome.

Accession
PA3393
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
nosD PA3393
Status
annotated
Amino acids
428
Structure source
AlphaFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.511
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records
Show feature table
Start End DB Term Name
1 12 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
72 209 Gene3D G3DSA:2.160.20.10 -
72 209 InterPro IPR012334 Pectin lyase fold
13 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
41 420 NCBIfam TIGR04247 nitrous oxide reductase family maturation protein NosD
41 420 InterPro IPR026464 Nitrous oxide reductase family maturation protein NosD
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
85 113 SMART SM00710 pbh1
85 113 InterPro IPR006626 Parallel beta-helix repeat
167 188 SMART SM00710 pbh1
167 188 InterPro IPR006626 Parallel beta-helix repeat
211 232 SMART SM00710 pbh1
211 232 InterPro IPR006626 Parallel beta-helix repeat
189 210 SMART SM00710 pbh1
189 210 InterPro IPR006626 Parallel beta-helix repeat
233 255 SMART SM00710 pbh1
233 255 InterPro IPR006626 Parallel beta-helix repeat
315 353 SMART SM00710 pbh1
315 353 InterPro IPR006626 Parallel beta-helix repeat
115 136 SMART SM00710 pbh1
115 136 InterPro IPR006626 Parallel beta-helix repeat
292 313 SMART SM00710 pbh1
292 313 InterPro IPR006626 Parallel beta-helix repeat
137 166 SMART SM00710 pbh1
137 166 InterPro IPR006626 Parallel beta-helix repeat
37 407 SUPERFAMILY SSF51126 Pectin lyase-like
37 407 InterPro IPR011050 Pectin lyase fold/virulence factor
30 428 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
223 353 Gene3D G3DSA:2.160.20.10 -
223 353 InterPro IPR012334 Pectin lyase fold
288 329 NCBIfam TIGR03804 parallel beta-helix repeat (two copies)
288 329 InterPro IPR022441 Parallel beta-helix repeat-2
193 367 SMART SM00722 complete
193 367 InterPro IPR006633 Carbohydrate-binding/sugar hydrolysis domain
38 187 SMART SM00722 complete
38 187 InterPro IPR006633 Carbohydrate-binding/sugar hydrolysis domain
144 356 Pfam PF05048 Periplasmic copper-binding protein (NosD)
144 356 InterPro IPR007742 Periplasmic copper-binding protein NosD, beta helix domain
1 29 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3393
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.511