Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3405
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: hasE PA3405
Status: annotated
Amino acids: 443
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.594

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
46	443	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
422	442	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
364	387	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
407	422	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
75	95	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
307	328	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
340	364	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
33	56	PRINTS	PR01490	Gram-negative bacterial RTX secretion protein D signature
20	437	PANTHER	PTHR30386	MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
35	399	Pfam	PF00529	Cation efflux system protein CusB domain 1
35	399	InterPro	IPR043602	Cation efflux system protein CusB, domain 1
146	297	Gene3D	G3DSA:1.10.287.1490	-
22	443	NCBIfam	TIGR01843	HlyD family type I secretion periplasmic adaptor subunit
22	443	InterPro	IPR010129	Type I secretion membrane fusion protein, HlyD family
1	26	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
262	296	Coils	Coil	Coil
305	425	Gene3D	G3DSA:2.40.30.170	-
174	208	Coils	Coil	Coil
67	126	Gene3D	G3DSA:2.40.50.100	-
266	346	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
27	45	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
27	46	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3405	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.594
2				0.329
1				0.219

PA3405