Protein profile

PA3407

heme acquisition protein HasA

Genome: NC_002516.2

Gene: PA3407 hasAp Structure source: Experimental + AlphaFold UniProt G3XD33 UniProt O69756
Export view
Amino acids 205
Annotations 1
Features 7
PDB binders 4
Druggability 0.546

Overview

Basic information about this protein and its source genome.

Accession
PA3407
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3407 hasAp
Status
annotated
Amino acids
205
Structure source
Experimental + AlphaFold
GO
GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.546
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
1 205 PIRSF PIRSF019876 HasA
1 205 InterPro IPR010495 Haem-binding HasA
2 176 SUPERFAMILY SSF54621 Heme-binding protein A (HasA)
2 176 InterPro IPR036912 Haem-binding HasA superfamily
1 184 Gene3D G3DSA:3.30.1500.10 -
1 184 InterPro IPR036912 Haem-binding HasA superfamily
1 205 Pfam PF06438 Heme-binding protein A (HasA)

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

34 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6U87
X-ray 1.30 Å A
100.0% 1-205
PDBe RCSB PDBj File
Viewing
PDB 6URB
X-ray 2.10 Å A,B
97.6% 1-200
PDBe RCSB PDBj File
Loaded
PDB 4O6U
X-ray 0.89 Å A
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 4O6Q
X-ray 0.95 Å A
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 5IQX
X-ray 1.05 Å A
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 3MOL
X-ray 1.20 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 4O6T
X-ray 1.25 Å A
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 5XA4
X-ray 1.30 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 4O6S
X-ray 1.32 Å A
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 7VF7
X-ray 1.35 Å A,B,C
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 7VF8
X-ray 1.35 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 5XIC
X-ray 1.45 Å A,B,C,D
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 3W8M
X-ray 1.46 Å A
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 7EMO
X-ray 1.50 Å A,B,C
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 7EMP
X-ray 1.50 Å A,B,C
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 7EMQ
X-ray 1.50 Å A,B,C
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 3WAH
X-ray 1.54 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 3MOK
X-ray 1.55 Å A
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 7EMR
X-ray 1.55 Å A,B,C
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 3ELL
X-ray 1.70 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 3W8O
X-ray 1.85 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 5XKB
X-ray 1.90 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 5IQW
X-ray 1.95 Å A
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 7VM1
X-ray 2.00 Å A,B,C,D
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 5XIE
X-ray 2.05 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 3MOM
X-ray 2.25 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 5XIB
X-ray 2.30 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 5XHL
X-ray 2.50 Å A,B
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 6JLG
X-ray 2.50 Å A,B,C,D,E,F,G,H
89.8% 1-184
PDBe RCSB PDBj File
Loaded
PDB 7EMW
X-ray 1.12 Å A
89.3% 1-183
PDBe RCSB PDBj File
Loaded
PDB 7EMU
X-ray 1.35 Å A
89.3% 1-183
PDBe RCSB PDBj File
Loaded
PDB 7EMV
X-ray 1.45 Å A
89.3% 1-183
PDBe RCSB PDBj File
Loaded
PDB 7EMT
X-ray 1.80 Å A
89.3% 1-183
PDBe RCSB PDBj File
Loaded
PDB 7EMS
X-ray 1.85 Å A,B,C
89.3% 1-183
PDBe RCSB PDBj File
Loaded
AlphaFold PA3407
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
PE8
5XIC 1.45 Å Open crystal
370.4 Da LogP -0.91 TPSA 105.1 ✓ Ro5 ✓ Clean C(COCCOCCOCCOCCOCCOCCOCCO)O
VPC
5XHL 2.50 Å Open crystal
— — — c1ccc2c(c1)c3n4c2N=C5c6ccccc6C7=[N]5[Ga]48N9C(=…
WPC
3W8O 1.85 Å Open crystal
568.4 Da LogP 3.80 TPSA 65.3 1 viol. ✓ Clean c1ccc2c(c1)c3nc-4[n+]5c(nc6c7ccccc7c8n6[Fe]59n3…
YOM
3W8M 1.46 Å Open crystal
370.2 Da LogP 3.83 TPSA 24.5 ✓ Ro5 ✓ Clean c1ccc2c(c1)C=[N+]3c4ccccc4[N+]5=Cc6ccccc6O[Fe]3…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.