Protein profile

PA3408

heme uptake outer membrane receptor HasR

Genome: NC_002516.2

Gene: hasR PA3408 Structure source: AlphaFold UniProt Q9HYJ7
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Amino acids 891
Annotations 11
Features 26
PDB binders 8
Druggability 0.509

Overview

Basic information about this protein and its source genome.

Accession
PA3408
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
hasR PA3408
Status
annotated
Amino acids
891
Structure source
AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0015232 Enables the transfer of heme from one side of a membrane to the other. GO:0015344 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0038023 Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.509
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

11 GO

Gene Ontology (GO)

11
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0015232 Enables the transfer of heme from one side of a membrane to the other.
  • GO:0015344 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in).
  • GO:0038023 Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
  • GO:0007166 The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
  • GO:0015886 The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0044718 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
273 891 Gene3D G3DSA:2.40.170.20 -
273 891 InterPro IPR036942 TonB-dependent receptor-like, beta-barrel domain superfamily
146 272 Gene3D G3DSA:2.170.130.10 -
146 272 InterPro IPR037066 TonB-dependent receptor, plug domain superfamily
37 891 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
28 36 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
46 146 FunFam G3DSA:3.55.50.30:FF:000002 Probable TonB-dependent receptor
128 891 NCBIfam TIGR01786 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor
128 891 InterPro IPR010949 TonB-dependent haemoglobin/transferrin/lactoferrin receptor
1 15 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
46 145 Gene3D G3DSA:3.55.50.30 -
378 889 Pfam PF00593 TonB dependent receptor
378 889 InterPro IPR000531 TonB-dependent receptor-like, beta-barrel
1 36 Phobius SIGNAL_PEPTIDE Signal peptide region
138 891 SUPERFAMILY SSF56935 Porins
138 891 PANTHER PTHR30069 TONB-DEPENDENT OUTER MEMBRANE RECEPTOR
138 891 InterPro IPR039426 TonB-dependent receptor-like
75 126 SMART SM00965 STN_2
75 126 InterPro IPR011662 Secretin/TonB, short N-terminal domain
16 27 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 36 SignalP_EUK SignalP-noTM SignalP-noTM
150 257 Pfam PF07715 TonB-dependent Receptor Plug Domain
150 257 InterPro IPR012910 TonB-dependent receptor, plug domain
154 891 CDD cd01347 ligand_gated_channel
134 891 NCBIfam TIGR01785 TonB-dependent heme/hemoglobin receptor family protein
134 891 InterPro IPR011276 TonB-dependent haem/haemoglobin receptor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3408
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
36 0.509
18 0.478
1 0.444

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

58 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
6L0
6Z8A
Q9I116 598.7 Da LogP 0.63 TPSA 208.9 2 viol. ✓ Clean C1CCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(C/C=C/CC…
C8E
6I98
Q9I116 306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO
FLC
1PO0
P13036 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
FTT
6I98
Q9I116 244.4 Da LogP 3.74 TPSA 57.5 ✓ Ro5 ✓ Clean CCCCCCCCCCC[C@H](CC(=O)O)O
HTO
1KMO
P13036 148.2 Da LogP -0.11 TPSA 60.7 ✓ Ro5 ✓ Clean CCCC[C@H]([C@@H](CO)O)O
LDA
1KMO
P13036 229.4 Da LogP 4.48 TPSA 23.1 ✓ Ro5 ✓ Clean CCCCCCCCCCCC[N+](C)(C)[O-]
N8E
2W16
P48632 350.5 Da LogP 2.42 TPSA 66.4 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCOCCO
OES
2HDF
P17315 206.4 Da LogP 2.09 TPSA 37.3 ✓ Ro5 ✓ Clean CCCCCCCC[S@@](=O)CCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.