Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3430
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3430
Status: annotated
Amino acids: 259
Structure source: AlphaFold

GO

GO:0005856 A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. GO:0051015 Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. GO:0046872 Binding to a metal ion. GO:0005996 The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 50.704
Human E-value: 4.43e-15
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.692

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MTAVHSLPADVQAQVSAAEWQTRVDLAACYRLVALHGWDDLIFTHISAKVPGTEDFLINPFGLMFHEITASSLVKVDASGKKLMDSPYEINPAGYTIHSAVHEVRHDVECVLHTHTAAGIAVSCQKQGLLPLSQQSLFVLSSLSYHAYEGVALNHEEKARLQADLGASNFLILPNHGLLTCGGSIADTFLMMFTLQRACEVQVMAQSGGAELIHIPGQILAGARDMIAGVMRSKTGMGGQLAWPALLRKLDQQNPGYRQ

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0005856 A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
GO:0051015 Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
GO:0046872 Binding to a metal ion.
GO:0005996 The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
9	259	Gene3D	G3DSA:3.40.225.10	-
9	259	InterPro	IPR036409	Class II aldolase/adducin N-terminal domain superfamily
3	258	PANTHER	PTHR10672	ADDUCIN
19	220	SUPERFAMILY	SSF53639	AraD/HMP-PK domain-like
19	220	InterPro	IPR036409	Class II aldolase/adducin N-terminal domain superfamily
24	203	SMART	SM01007	Aldolase_II_2
24	203	InterPro	IPR001303	Class II aldolase/adducin N-terminal
11	259	FunFam	G3DSA:3.40.225.10:FF:000013	Class II aldolase
25	203	Pfam	PF00596	Class II Aldolase and Adducin N-terminal domain
25	203	InterPro	IPR001303	Class II aldolase/adducin N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3430	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.692
2				0.259

PA3430