Protein profile

PA3445

hypothetical protein

Genome: NC_002516.2

Gene: PA3445 Structure source: AlphaFold UniProt Q9HYG1
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Amino acids 323
Annotations 3
Features 19
PDB binders 3
Druggability 0.973

Overview

Basic information about this protein and its source genome.

Accession
PA3445
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3445
Status
annotated
Amino acids
323
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0042626 Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.973
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0042626 Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
32 313 NCBIfam TIGR01728 aliphatic sulfonate ABC transporter substrate-binding protein
32 313 InterPro IPR010067 Aliphatic sulfonates-binding protein
30 256 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
7 303 PANTHER PTHR30024 ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED
1 24 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
34 306 Gene3D G3DSA:3.40.190.10 -
9 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
1 8 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
31 305 CDD cd13557 PBP2_SsuA
56 250 Pfam PF09084 NMT1/THI5 like
56 250 InterPro IPR015168 SsuA/THI5-like
31 247 SMART SM00062 AABind_6
31 247 InterPro IPR001638 Solute-binding protein family 3/N-terminal domain of MltF
112 211 FunFam G3DSA:3.40.190.10:FF:000050 Sulfonate ABC transporter substrate-binding protein
112 211 Gene3D G3DSA:3.40.190.10 -
25 323 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3445
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.973
3 0.564

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

33 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
LUQ
6ST0
Q47537 182.2 Da LogP -2.05 TPSA 109.5 ✓ Ro5 ✓ Clean C(CS(=O)(=O)O)NCC(=O)N
P7I
6SSY
Q47537 125.1 Da LogP -0.88 TPSA 83.5 ✓ Ro5 ✓ Clean C(CP(=O)(O)O)N
TAU
6STL
Q47537 125.1 Da LogP -1.17 TPSA 80.4 ✓ Ro5 ✓ Clean C(CS(=O)(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.