Protein profile

PA3458

transcriptional regulator

Genome: NC_002516.2

Gene: PA3458 Structure source: AlphaFold UniProt Q9HYE8
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Amino acids 157
Annotations 3
Features 21
PDB binders 2
Druggability 0.807

Overview

Basic information about this protein and its source genome.

Accession
PA3458
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3458
Status
annotated
Amino acids
157
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.807
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
13 145 ProSiteProfiles PS50995 MarR-type HTH domain profile.
13 145 InterPro IPR000835 MarR-type HTH domain
57 73 PRINTS PR00598 Bacterial regulatory protein MarR family signature
57 73 InterPro IPR000835 MarR-type HTH domain
93 109 PRINTS PR00598 Bacterial regulatory protein MarR family signature
93 109 InterPro IPR000835 MarR-type HTH domain
74 89 PRINTS PR00598 Bacterial regulatory protein MarR family signature
74 89 InterPro IPR000835 MarR-type HTH domain
8 147 Gene3D G3DSA:1.10.10.10 -
8 147 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
32 133 SMART SM00347 marrlong4
32 133 InterPro IPR000835 MarR-type HTH domain
42 93 CDD cd00090 HTH_ARSR
42 93 InterPro IPR011991 ArsR-like helix-turn-helix domain
6 146 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
6 146 InterPro IPR036390 Winged helix DNA-binding domain superfamily
12 144 PANTHER PTHR33164 TRANSCRIPTIONAL REGULATOR, MARR FAMILY
12 144 InterPro IPR039422 Transcription regulators MarR/SlyA-like
8 147 FunFam G3DSA:1.10.10.10:FF:000682 MarR family transcriptional regulator
40 97 Pfam PF01047 MarR family
40 97 InterPro IPR000835 MarR-type HTH domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3458
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.807
1 0.794

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
4HP
5AIP
Q7DD70 152.1 Da LogP 1.02 TPSA 57.5 ✓ Ro5 ✓ Clean c1cc(ccc1CC(=O)O)O
WCA
6C28
Q6N8V9 913.7 Da LogP 0.08 TPSA 383.9 3 viol. ✓ Clean CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.