Protein profile

PA3469

hypothetical protein

Genome: NC_002516.2

Gene: PA3469 Structure source: AlphaFold UniProt Q9HYD7
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Amino acids 180
Annotations 2
Features 7
PDB binders 0
Druggability 0.781

Overview

Basic information about this protein and its source genome.

Accession
PA3469
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3469
Status
annotated
Amino acids
180
Structure source
AlphaFold
GO
GO:0008703 Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH. GO:0009231 The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.781
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008703 Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH.
  • GO:0009231 The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
3 176 Gene3D G3DSA:3.40.430.10 Dihydrofolate Reductase, subunit A
3 176 InterPro IPR024072 Dihydrofolate reductase-like domain superfamily
2 173 PANTHER PTHR38011 DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)
3 174 SUPERFAMILY SSF53597 Dihydrofolate reductase-like
3 174 InterPro IPR024072 Dihydrofolate reductase-like domain superfamily
93 166 Pfam PF01872 RibD C-terminal domain
93 166 InterPro IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3469
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.781