Protein profile

PA3474

hypothetical protein

Genome: NC_002516.2

Gene: PA3474 Structure source: AlphaFold UniProt O68826
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Amino acids 286
Annotations 2
Features 42
PDB binders 0
Druggability 0.831

Overview

Basic information about this protein and its source genome.

Accession
PA3474
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3474
Status
annotated
Amino acids
286
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.831
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

42 records
Show feature table
Start End DB Term Name
203 222 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
35 131 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
204 223 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
135 153 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
56 78 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
30 49 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
235 254 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
255 259 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
84 102 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
130 134 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
224 234 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
154 173 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
193 203 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
103 108 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
79 83 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
278 286 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
50 55 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
258 280 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
174 193 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
29 49 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 25 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
176 282 SUPERFAMILY SSF103481 Multidrug resistance efflux transporter EmrE
108 127 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
139 277 Pfam PF00892 EamA-like transporter family
139 277 InterPro IPR000620 EamA domain
3 128 Pfam PF00892 EamA-like transporter family
3 128 InterPro IPR000620 EamA domain
11 274 NCBIfam TIGR00950 carboxylate/amino acid/amine transporter
11 274 InterPro IPR004779 Carboxylate/Amino Acid/Amine Transporter
20 28 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
82 101 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
260 277 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
131 153 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 274 PANTHER PTHR22911 ACYL-MALONYL CONDENSING ENZYME-RELATED
174 192 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
109 129 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
56 78 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
235 254 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3474
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.831
8 0.266