Protein profile

PA3480

deoxycytidine triphosphate deaminase

Genome: NC_002516.2

Gene: PA3480 dcd Structure source: AlphaFold UniProt Q9HYC9
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Amino acids 188
Annotations 7
Features 14
PDB binders 4
Druggability 0.785

Overview

Basic information about this protein and its source genome.

Accession
PA3480
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3480 dcd
Status
annotated
Amino acids
188
Structure source
AlphaFold
EC
3.5.4.13
GO
GO:0008829 Catalysis of the reaction: dCTP + H2O + H+ = dUTP + NH4+. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0006235 The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. GO:0006226 The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate). GO:0006229 The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate. GO:0015949 The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.785
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0008829 Catalysis of the reaction: dCTP + H2O + H+ = dUTP + NH4+.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
  • GO:0006235 The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
  • GO:0006226 The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate).
  • GO:0006229 The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate.
  • GO:0015949 The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 188 PANTHER PTHR42680 DCTP DEAMINASE
76 184 Pfam PF00692 dUTPase
76 184 InterPro IPR029054 dUTPase-like
1 160 Gene3D G3DSA:2.70.40.10 -
1 160 InterPro IPR036157 dUTPase-like superfamily
74 159 CDD cd07557 trimeric_dUTPase
74 159 InterPro IPR033704 dUTPase, trimeric
3 187 SUPERFAMILY SSF51283 dUTPase-like
3 187 InterPro IPR036157 dUTPase-like superfamily
1 160 FunFam G3DSA:2.70.40.10:FF:000001 dCTP deaminase
1 188 Hamap MF_00146 dCTP deaminase, dUMP-forming [dcd].
1 188 InterPro IPR011962 dCTP deaminase
4 187 NCBIfam TIGR02274 dCTP deaminase
4 187 InterPro IPR011962 dCTP deaminase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3480
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.785
1 0.516

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
DCP
1XS4
P28248 467.2 Da LogP -1.18 TPSA 250.2 2 viol. ✓ Clean C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO[P@@](=…
DUT
1XS1
P28248 468.1 Da LogP -1.47 TPSA 244.1 2 viol. ✓ Clean C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO[P@@](=…
TTP
2J4Q
P28248 482.2 Da LogP -1.16 TPSA 244.1 2 viol. ✓ Clean CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[P@]…
TYD
2J4Q
P28248 402.2 Da LogP -1.28 TPSA 197.6 ✓ Ro5 ✓ Clean CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO[P@]…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.