Protein profile

PA3481

hypothetical protein

Genome: NC_002516.2

Gene: PA3481 Structure source: AlphaFold UniProt Q9HYC8
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Amino acids 364
Annotations 8
Features 21
PDB binders 2
Druggability 0.822

Overview

Basic information about this protein and its source genome.

Accession
PA3481
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3481
Status
annotated
Amino acids
364
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0140663 Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
54.839
Human E-value
1.62e-07
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.822
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0140663 Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis.
  • GO:0046872 Binding to a metal ion.
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
97 342 Pfam PF10609 NUBPL iron-transfer P-loop NTPase
97 342 InterPro IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
4 82 SUPERFAMILY SSF117916 Fe-S cluster assembly (FSCA) domain-like
4 82 InterPro IPR034904 Fe-S cluster assembly domain superfamily
206 222 ProSitePatterns PS01215 Mrp family signature.
206 222 InterPro IPR000808 Mrp, conserved site
6 78 Pfam PF01883 Iron-sulfur cluster assembly protein
6 78 InterPro IPR002744 MIP18 family-like
2 95 Gene3D G3DSA:3.30.300.130 -
2 95 InterPro IPR034904 Fe-S cluster assembly domain superfamily
96 351 Gene3D G3DSA:3.40.50.300 -
96 351 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
100 313 CDD cd02037 Mrp_NBP35
100 313 InterPro IPR019591 Mrp/NBP35 ATP-binding protein
93 343 Hamap MF_02040 Iron-sulfur cluster carrier protein.
93 343 InterPro IPR019591 Mrp/NBP35 ATP-binding protein
5 347 PANTHER PTHR42961 IRON-SULFUR PROTEIN NUBPL
5 347 InterPro IPR044304 Iron-sulfur protein NUBPL-like
89 327 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
89 327 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
94 348 FunFam G3DSA:3.40.50.300:FF:000418 Iron-sulfur cluster carrier protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3481
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.822
12 0.301
5 0.259

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ACP
5AUP
Q5JIH4 505.2 Da LogP -1.52 TPSA 269.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
ANP
5J1J
G3XD64 506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.