Protein profile

PA3485

hypothetical protein

Genome: NC_002516.2

Gene: tsi3 PA3485 Structure source: Experimental + AlphaFold UniProt Q9HYC4
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Amino acids 145
Annotations 1
Features 12
PDB binders 0
Druggability 0.246

Overview

Basic information about this protein and its source genome.

Accession
PA3485
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
tsi3 PA3485
Status
annotated
Amino acids
145
Structure source
Experimental + AlphaFold
GO
GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.246
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
19 145 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
15 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
82 96 MobiDBLite mobidb-lite consensus disorder prediction
53 96 MobiDBLite mobidb-lite consensus disorder prediction
3 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
23 145 Gene3D G3DSA:2.60.120.1690 -
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 16 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
34 145 NCBIfam NF038331 Tsi3 family protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

6 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3WA5
X-ray 1.90 Å B
100.0% 1-145
PDBe RCSB PDBj File
Viewing
PDB 4M5F
X-ray 2.50 Å B
86.2% 21-145
PDBe RCSB PDBj File
Loaded
PDB 4LUQ
X-ray 1.77 Å C,D
84.8% 23-145
PDBe RCSB PDBj File
Loaded
PDB 4N80
X-ray 2.40 Å B
84.1% 23-144
PDBe RCSB PDBj File
Loaded
PDB 4N7S
X-ray 2.10 Å B,D
82.1% 27-145
PDBe RCSB PDBj File
Loaded
PDB 4N88
X-ray 2.80 Å B,D
82.1% 27-145
PDBe RCSB PDBj File
Loaded
AlphaFold PA3485
AlphaFold — — full sequence — Loaded
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