Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3490
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3490 rnfB
Status: annotated
Amino acids: 188
Structure source: AlphaFold

EC

7.-.-.-

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0046872 Binding to a metal ion. GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.78

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

7.-.-.-

Gene Ontology (GO)

6

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
GO:0046872 Binding to a metal ion.
GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records

Show feature table

Start	End	DB	Term	Name
4	17	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	17	SignalP_EUK	SignalP-TM	SignalP-TM
26	188	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
106	160	Pfam	PF14697	4Fe-4S dicluster domain
1	3	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
37	87	FunFam	G3DSA:1.10.15.40:FF:000001	Ion-translocating oxidoreductase complex subunit B
143	154	ProSitePatterns	PS00198	4Fe-4S ferredoxin-type iron-sulfur binding region signature.
143	154	InterPro	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site
104	133	ProSiteProfiles	PS51379	4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
104	133	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
37	82	Gene3D	G3DSA:1.10.15.40	-
1	25	Phobius	SIGNAL_PEPTIDE	Signal peptide region
18	25	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
134	163	ProSiteProfiles	PS51379	4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
134	163	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
36	175	PANTHER	PTHR42859	OXIDOREDUCTASE
32	90	ProSiteProfiles	PS51656	4Fe-4S domain profile.
32	90	InterPro	IPR007202	4Fe-4S domain
5	27	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
44	75	Pfam	PF04060	Putative Fe-S cluster
44	75	InterPro	IPR007202	4Fe-4S domain
83	172	Gene3D	G3DSA:3.30.70.20	-
40	172	SUPERFAMILY	SSF54862	4Fe-4S ferredoxins
1	187	NCBIfam	TIGR01944	RnfABCDGE type electron transport complex subunit B
1	187	InterPro	IPR010207	Ion-translocating oxidoreductase complex, RnfB/RsxB
4	165	Hamap	MF_00463	Ion-translocating oxidoreductase complex subunit B [rsxB].
4	165	InterPro	IPR010207	Ion-translocating oxidoreductase complex, RnfB/RsxB
3	186	PIRSF	PIRSF005784	RnfB
3	186	InterPro	IPR016463	Electron transport complex, RnfB/RsxB, Proteobacteria

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3490	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.78
3				0.674
2				0.453

PA3490