Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3491
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3491 rnfC
Status: annotated
Amino acids: 774
Structure source: AlphaFold

EC

7.-.-.-

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0046872 Binding to a metal ion. GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.606

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

7.-.-.-

Gene Ontology (GO)

6

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
GO:0046872 Binding to a metal ion.
GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

36 records

Show feature table

Start	End	DB	Term	Name
463	492	MobiDBLite	mobidb-lite	consensus disorder prediction
290	337	Pfam	PF10531	SLBB domain
290	337	InterPro	IPR019554	Soluble ligand binding domain
659	706	Coils	Coil	Coil
131	275	Pfam	PF01512	Respiratory-chain NADH dehydrogenase 51 Kd subunit
131	275	InterPro	IPR011538	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
428	488	Coils	Coil	Coil
6	106	Pfam	PF13375	RnfC Barrel sandwich hybrid domain
6	106	InterPro	IPR026902	RnfC Barrel sandwich hybrid domain
369	421	Pfam	PF12838	4Fe-4S dicluster domain
369	421	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
519	539	Coils	Coil	Coil
463	483	MobiDBLite	mobidb-lite	consensus disorder prediction
754	774	Coils	Coil	Coil
726	746	Coils	Coil	Coil
324	437	SUPERFAMILY	SSF46548	alpha-helical ferredoxin
617	644	Coils	Coil	Coil
87	294	SUPERFAMILY	SSF142019	Nqo1 FMN-binding domain-like
87	294	InterPro	IPR037225	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
366	422	Gene3D	G3DSA:3.30.70.20	-
1	758	Hamap	MF_00461	Ion-translocating oxidoreductase complex subunit C [rsxC].
1	758	InterPro	IPR010208	Ion-translocating oxidoreductase complex, subunit RnfC/RsxC
4	438	NCBIfam	TIGR01945	RnfABCDGE type electron transport complex subunit C
4	438	InterPro	IPR010208	Ion-translocating oxidoreductase complex, subunit RnfC/RsxC
552	572	Coils	Coil	Coil
3	614	PANTHER	PTHR43034	ION-TRANSLOCATING OXIDOREDUCTASE COMPLEX SUBUNIT C
3	614	InterPro	IPR010208	Ion-translocating oxidoreductase complex, subunit RnfC/RsxC
584	611	Coils	Coil	Coil
136	283	Gene3D	G3DSA:3.40.50.11540	-
136	283	InterPro	IPR037225	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
408	419	ProSitePatterns	PS00198	4Fe-4S ferredoxin-type iron-sulfur binding region signature.
408	419	InterPro	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site
399	428	ProSiteProfiles	PS51379	4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
399	428	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
359	389	ProSiteProfiles	PS51379	4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
359	389	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3491	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.606
2				0.485

PA3491