Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3493
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3493 rnfG
Status: annotated
Amino acids: 214
Structure source: AlphaFold

EC

7.-.-.-

GO

GO:1990204 Any protein complex that possesses oxidoreductase activity. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016651 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.766

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

7.-.-.-

Gene Ontology (GO)

7

GO:1990204 Any protein complex that possesses oxidoreductase activity.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0009055 A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.
GO:0010181 Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
GO:0016651 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
GO:0022900 A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
1	12	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	32	Phobius	SIGNAL_PEPTIDE	Signal peptide region
25	32	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
33	214	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13	24	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
7	207	PANTHER	PTHR36118	ION-TRANSLOCATING OXIDOREDUCTASE COMPLEX SUBUNIT G
7	207	InterPro	IPR010209	Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
105	194	Pfam	PF04205	FMN-binding domain
105	194	InterPro	IPR007329	FMN-binding
105	197	SMART	SM00900	FMN_bind_2
105	197	InterPro	IPR007329	FMN-binding
12	34	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
14	198	NCBIfam	TIGR01947	RnfABCDGE type electron transport complex subunit G
14	198	InterPro	IPR010209	Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
1	210	PIRSF	PIRSF006091	E_trnsport_RnfG
1	210	InterPro	IPR010209	Ion-translocating oxidoreductase complex, subunit RnfG/RsxG
6	199	Hamap	MF_00479	Ion-translocating oxidoreductase complex subunit G [rsxG].
6	199	InterPro	IPR010209	Ion-translocating oxidoreductase complex, subunit RnfG/RsxG

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3493	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.766

PA3493