Protein profile

PA3499

hypothetical protein

Genome: NC_002516.2

Gene: PA3499 Structure source: Experimental + AlphaFold UniProt Q9HYB0
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Amino acids 144
Annotations 2
Features 9
PDB binders 0
Druggability 0.819

Overview

Basic information about this protein and its source genome.

Accession
PA3499
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3499
Status
annotated
Amino acids
144
Structure source
Experimental + AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239 Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.819
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0019239 Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 144 Gene3D G3DSA:3.30.1330.40 -
1 144 InterPro IPR035959 RutC-like superfamily
16 133 Pfam PF01042 Endoribonuclease L-PSP
16 133 InterPro IPR006175 YjgF/YER057c/UK114 family
13 132 PANTHER PTHR11803 2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA
13 132 InterPro IPR006175 YjgF/YER057c/UK114 family
20 132 CDD cd00448 YjgF_YER057c_UK114_family
16 134 SUPERFAMILY SSF55298 YjgF-like
16 134 InterPro IPR035959 RutC-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2IG8
X-ray 1.90 Å A,B,C
100.0% 1-144
PDBe RCSB PDBj File
Viewing
AlphaFold PA3499
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.819

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.66 0.338

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

Show only:
Ligand UniProt (homolog) pchembl MW · LogP · TPSA Lipinski PAINS SMILES
FCN P0AGL2 — 138.1 Da LogP -0.09 TPSA 70.1 ✓ Ro5 ✓ Clean C[C@H]1[C@H](O1)P(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.