Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3512
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3512
Status: annotated
Amino acids: 258
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.904

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records

Show feature table

Start	End	DB	Term	Name
1	7	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
120	124	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
125	147	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
168	199	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
200	218	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	23	SignalP_EUK	SignalP-noTM	SignalP-noTM
54	234	SUPERFAMILY	SSF161098	MetI-like
54	234	InterPro	IPR035906	MetI-like superfamily
177	199	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
67	234	CDD	cd06261	TM_PBP2
67	234	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
87	97	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
77	246	Pfam	PF00528	Binding-protein-dependent transport system inner membrane component
77	246	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
20	23	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
48	246	FunFam	G3DSA:1.10.3720.10:FF:000161	Probable permease of ABC transporter
8	19	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
7	251	PANTHER	PTHR30151	ALKANE SULFONATE ABC TRANSPORTER-RELATED, MEMBRANE SUBUNIT
59	240	ProSiteProfiles	PS50928	ABC transporter integral membrane type-1 domain profile.
59	240	InterPro	IPR000515	ABC transporter type 1, transmembrane domain MetI-like
219	242	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
148	167	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
24	65	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
98	119	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
93	115	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
243	258	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
125	147	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
48	246	Gene3D	G3DSA:1.10.3720.10	-
48	246	InterPro	IPR035906	MetI-like superfamily
1	23	Phobius	SIGNAL_PEPTIDE	Signal peptide region
66	86	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	26	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
64	86	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
219	241	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3512	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.904
3				0.601
5				0.555

PA3512