Protein profile

PA3518

hypothetical protein

Genome: NC_002516.2

Gene: PA3518 Structure source: Experimental + AlphaFold UniProt Q9HY91
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Amino acids 328
Annotations 4
Features 12
PDB binders 0
Druggability 0.913

Overview

Basic information about this protein and its source genome.

Accession
PA3518
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3518
Status
annotated
Amino acids
328
Structure source
Experimental + AlphaFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0046872 Binding to a metal ion. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.913
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0046872 Binding to a metal ion.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
6 93 Gene3D G3DSA:1.10.1240.20 Lytic transglycosylase, superhelical linker domain
6 93 InterPro IPR037061 Lytic transglycosylase, superhelical linker domain superfamily
103 328 Gene3D G3DSA:1.20.910.10 -
103 328 InterPro IPR016084 Haem oxygenase-like, multi-helical
71 327 PANTHER PTHR40279 PQQC-LIKE PROTEIN
71 327 InterPro IPR039068 Pyrroloquinoline-quinone synthase-like
1 93 Pfam PF14515 Haem-oxygenase-associated N-terminal helices
1 93 InterPro IPR029474 Haem-oxygenase-associated, N-terminal helices
174 276 SMART SM01236 Haem_oxygenas_2_2
107 321 SUPERFAMILY SSF48613 Heme oxygenase-like
107 321 InterPro IPR016084 Haem oxygenase-like, multi-helical
155 276 Pfam PF14518 Iron-containing redox enzyme

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 8W1Q
X-ray 1.56 Å A,B
100.0% 1-328
PDBe RCSB PDBj File
Viewing
PDB 3BJD
X-ray 1.85 Å A,B,C
100.0% 1-328
PDBe RCSB PDBj File
Loaded
PDB 9B9M
X-ray 2.07 Å A,B,C,D
100.0% 1-328
PDBe RCSB PDBj File
Loaded
PDB 9B9N
X-ray 2.28 Å A,B
100.0% 1-328
PDBe RCSB PDBj File
Metadata only
PDB 9B9O
X-ray 2.16 Å A,B
99.7% 2-328
PDBe RCSB PDBj File
Metadata only
AlphaFold PA3518
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.913
10 0.568
1 0.417

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.04 0.885
2 8.58 0.458
3 6.85 0.352
4 3.69 0.14
5 1.45 0.019