Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3523
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3523
Status: annotated
Amino acids: 385
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.846

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
55	277	Gene3D	G3DSA:2.40.30.170	-
1	33	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
1	32	Phobius	SIGNAL_PEPTIDE	Signal peptide region
33	385	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
9	20	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	25	SignalP_EUK	SignalP-noTM	SignalP-noTM
37	358	NCBIfam	TIGR01730	efflux RND transporter periplasmic adaptor subunit
37	358	InterPro	IPR006143	RND efflux pump, membrane fusion protein
62	286	Pfam	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion
62	286	InterPro	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain
1	8	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
96	169	Gene3D	G3DSA:1.10.287.470	Helix hairpin bin
1	22	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
2	372	PANTHER	PTHR30158	ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER
292	379	Gene3D	G3DSA:2.40.420.20	-
277	366	FunFam	G3DSA:2.40.420.20:FF:000001	Efflux RND transporter periplasmic adaptor subunit
50	293	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
21	32	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
61	204	Gene3D	G3DSA:2.40.50.100	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3523	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.846
2				0.523
1				0.286
5				0.223

PA3523