Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3530
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: bfd PA3530
Status: annotated
Amino acids: 73
Structure source: Experimental + AlphaFold

GO

GO:0051537 Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0051537 Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records

Show feature table

Start	End	DB	Term	Name
1	56	Gene3D	G3DSA:1.10.10.1100	-
1	56	InterPro	IPR041854	BFD-like [2Fe-2S]-binding domain superfamily
2	49	Pfam	PF04324	BFD-like [2Fe-2S] binding domain
2	49	InterPro	IPR007419	BFD-like [2Fe-2S]-binding domain
1	53	CDD	cd19945	Fer2_BFD
1	68	PANTHER	PTHR37424	BACTERIOFERRITIN-ASSOCIATED FERREDOXIN
1	56	FunFam	G3DSA:1.10.10.1100:FF:000007	(2Fe-2S)-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed PDB 4E6K structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

Loading 3D structure...

Legend High Medium Low

Structural evidence

4 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
PDB 4E6K	X-ray	2.00 Å	G,H,I	100.0% 1-73	PDBe RCSB PDBj File	Viewing
PDB 6E6Q	X-ray	1.20 Å	A,B	76.7% 1-56	PDBe RCSB PDBj File	Loaded
PDB 6E6S	X-ray	1.45 Å	A,B	76.7% 1-56	PDBe RCSB PDBj File	Loaded
PDB 6E6R	X-ray	1.50 Å	A	76.7% 1-56	PDBe RCSB PDBj File	Loaded
AlphaFold PA3530	AlphaFold	—	—	full sequence	—	Loaded

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Ligand	Source crystal	MW · LogP · TPSA	Lipinski	PAINS	SMILES
FES	4E6K 2.00 Å Open crystal	175.8 Da LogP 1.29 TPSA 0.0	✓ Ro5	✓ Clean	`S1[Fe]S[Fe]1`

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

No PDB ligands found through similar proteins.

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA3530