Amino acids
475
Annotations
3
Features
24
PDB binders
0
Druggability
0.704
Overview
Basic information about this protein and its source genome.
- Accession
- PA3543
- Gene
- PA3543 algK
- Status
- annotated
- Amino acids
- 475
- Structure source
- AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
GO:0005515 Binding to a protein.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- Localization
- Periplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
FPocket
0.704
Sequence
Primary amino-acid sequence viewer.
MKMPILPPLPLASRHLLLASAIALAAGCAGLPDQRLAQEALERGDLATAQSNYQALAAMGYADAQVGLADMQVASGDSAQQAKAEKLYREAAQTSPRARARLGKWLAAKPGASDAEHREAERLLSQAFEQGEDSALVPLIVLYLQYPQSWPEIDPQQRIDQWRARGLPQADLAQIILYRTQGTYAQHLGEIEQVCQRWLRRMDVCWYELATVYQMQGNAEKQKVLLEQLRAAYKAGRVPGERVDSVAGVLADGELGQPDPQTAQALLEEIAPSYPAAWVSLAKLLYDYPDQGDLEKMLGYLKNAQDAAQPRAELLLGRLYYDGKWAPQDPRKAERHLLKAAASEPQANYYLGQIYRRGFLGKVYPQKAVDHLILAARAGQASADMALAQLWSQGRGIQPNRVNAYVFGQLAVQQQVPQASDLLGQIEAQLPPAERSQAQQLLKREQQSRGNNWQATVSLLQSQDSPINEEEPESL
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
3 GO
Gene Ontology (GO)
3- GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
- GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).
- GO:0005515 Binding to a protein.
Sequence Features
Domain/signature hits from InterPro and related databases.
24 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 16 | 26 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 31 | 475 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 28 | 461 | Gene3D | G3DSA:1.25.40.10 | Tetratricopeptide repeat domain |
| 28 | 461 | InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| 1 | 15 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 436 | 469 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 27 | 30 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 1 | 25 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM |
| 13 | 459 | NCBIfam | NF038194 | alginate biosynthesis TPR repeat lipoprotein AlgK |
| 256 | 449 | SUPERFAMILY | SSF81901 | HCP-like |
| 1 | 25 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM |
| 310 | 344 | SMART | SM00671 | sel1 |
| 310 | 344 | InterPro | IPR006597 | Sel1-like repeat |
| 62 | 96 | SMART | SM00671 | sel1 |
| 62 | 96 | InterPro | IPR006597 | Sel1-like repeat |
| 381 | 416 | SMART | SM00671 | sel1 |
| 381 | 416 | InterPro | IPR006597 | Sel1-like repeat |
| 345 | 380 | SMART | SM00671 | sel1 |
| 345 | 380 | InterPro | IPR006597 | Sel1-like repeat |
| 274 | 430 | PANTHER | PTHR11102 | SEL-1-LIKE PROTEIN |
| 1 | 30 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 436 | 475 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 1 | 30 | SignalP_EUK | SignalP-noTM | SignalP-noTM |
| 1 | 28 | ProSiteProfiles | PS51257 | Prokaryotic membrane lipoprotein lipid attachment site profile. |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Legend
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Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA3543
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.387 |