Protein profile

PA3548

alginate o-acetylase AlgI

Genome: NC_002516.2

Gene: algI PA3548 Structure source: AlphaFold UniProt Q51392
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Amino acids 520
Annotations 5
Features 42
PDB binders 0
Druggability 0.742

Overview

Basic information about this protein and its source genome.

Accession
PA3548
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
algI PA3548
Status
annotated
Amino acids
520
Structure source
AlphaFold
EC
2.3.1.-
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0051979 The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate. GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.742
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MVFSSNVFLFLFLPVFLGLYYLSGERYRNLLLLIASYVFYAWWRVDFLLLFAGVTVFNYWIGLRIGAAGVRTRAAQRWLILGVVVDLCVLGYFKYANFGVDSLNEIITSFGMQPFVLTHILLPIGISFYTFESISYIIDVYRGDTPATHNLIDFAAFVAIFPHLIAGPVLRFKDLVDQFNHRTHTVDKFAEGCTRFMQGFVKKVFIADTLAALADHCFALQNPTTGDAWLGALAYTAQLYFDFSGYSDMAIGLGLMMGFRFMENFNQPYISQSITEFWRRWHISLSTWLRDYLYISLGGNRGSTFQTYRNLFLTMLLGGLWHGANFTYIIWGAWHGMWLAIERALGVNAAPRVLNPLKWVITFLLVVIGWVIFRAENLQVAWRMYEAMFSFGTWQLSELNRANLTGLQVGTLVLAYLVLAFFGLRQFYNQPLQTKAPKAAANSDEVAADGPASAQPRAPREAAGDPAAIAYSPSGALVYQPSWLSQLPVLATRLALLLLFAASVLKLSAQSYSPFLYFQF

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
  • GO:0051979 The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate.
  • GO:0042121 The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).

Sequence Features

Domain/signature hits from InterPro and related databases.

42 records
Show feature table
Start End DB Term Name
506 520 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
6 22 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
150 170 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
353 375 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
483 505 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
96 114 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
311 334 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
311 333 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
354 373 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
404 424 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
239 261 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
171 242 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
402 424 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
44 48 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
483 505 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
374 403 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
148 378 Pfam PF03062 MBOAT, membrane-bound O-acyltransferase family
148 378 InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
1 520 PIRSF PIRSF500217 AlgI
1 520 InterPro IPR028362 Alginate O-acetyltransferase AlgI
115 138 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 397 PANTHER PTHR13285 ACYLTRANSFERASE
425 482 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
263 310 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
67 77 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
78 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
78 95 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
150 172 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
139 149 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
335 353 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
115 137 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
49 66 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 446 PIRSF PIRSF016636 AlgI_DltB
1 446 InterPro IPR024194 Alginate O-acetyltransferase AlgI/D-alanyl transfer protein DltB
474 520 PIRSF PIRSF016636 AlgI_DltB
474 520 InterPro IPR024194 Alginate O-acetyltransferase AlgI/D-alanyl transfer protein DltB
23 26 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
243 262 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3548
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.742
4 0.594
20 0.302
3 0.259