Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3571
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3571 mmsR
Status: annotated
Amino acids: 307
Structure source: AlphaFold

GO

GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:2000284 Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.489

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
GO:2000284 Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records

Show feature table

Start	End	DB	Term	Name
251	293	ProSitePatterns	PS00041	Bacterial regulatory proteins, araC family signature.
251	293	InterPro	IPR018062	HTH domain AraC-type, conserved site
50	301	PANTHER	PTHR46796	HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
202	245	Gene3D	G3DSA:1.10.10.60	-
220	299	Pfam	PF12833	Helix-turn-helix domain
220	299	InterPro	IPR018060	DNA binding HTH domain, AraC-type
246	302	Gene3D	G3DSA:1.10.10.60	-
201	299	ProSiteProfiles	PS01124	Bacterial regulatory proteins, araC family DNA-binding domain profile.
201	299	InterPro	IPR018060	DNA binding HTH domain, AraC-type
41	127	CDD	cd06986	cupin_MmsR-like_N
47	184	Pfam	PF02311	AraC-like ligand binding domain
47	184	InterPro	IPR003313	AraC-type arabinose-binding/dimerisation domain
36	187	SUPERFAMILY	SSF51215	Regulatory protein AraC
36	187	InterPro	IPR037923	Transcription regulator HTH-like
266	281	PRINTS	PR00032	AraC bacterial regulatory protein HTH signature
266	281	InterPro	IPR020449	Transcription regulator HTH, AraC- type
281	297	PRINTS	PR00032	AraC bacterial regulatory protein HTH signature
281	297	InterPro	IPR020449	Transcription regulator HTH, AraC- type
214	297	SMART	SM00342	aracneu4
214	297	InterPro	IPR018060	DNA binding HTH domain, AraC-type
203	246	SUPERFAMILY	SSF46689	Homeodomain-like
203	246	InterPro	IPR009057	Homeobox-like domain superfamily
47	187	Gene3D	G3DSA:2.60.120.280	Regulatory protein AraC
251	301	SUPERFAMILY	SSF46689	Homeodomain-like
251	301	InterPro	IPR009057	Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3571	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.489

PA3571