Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3583
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: glpR PA3583
Status: annotated
Amino acids: 251
Structure source: AlphaFold

GO

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0098531 A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. GO:0006071 The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. GO:0009892 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.561

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
GO:0098531 A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.
GO:0006071 The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
GO:0009892 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records

Show feature table

Start	End	DB	Term	Name
6	58	SMART	SM00420	deor2
6	58	InterPro	IPR001034	DeoR-type HTH domain
69	133	Gene3D	G3DSA:3.30.750.70	-
74	232	SUPERFAMILY	SSF100950	NagB/RpiA/CoA transferase-like
74	232	InterPro	IPR037171	NagB/RpiA transferase-like
3	58	ProSiteProfiles	PS51000	DeoR-type HTH domain profile.
3	58	InterPro	IPR001034	DeoR-type HTH domain
69	133	FunFam	G3DSA:3.30.750.70:FF:000001	DeoR/GlpR family transcriptional regulator
5	246	PANTHER	PTHR30363	HTH-TYPE TRANSCRIPTIONAL REGULATOR SRLR-RELATED
6	40	ProSitePatterns	PS00894	DeoR-type HTH domain signature.
6	40	InterPro	IPR018356	Transcription regulator, HTH DeoR-type, conserved site
3	68	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
3	68	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
24	38	PRINTS	PR00037	LacR bacterial regulatory protein HTH signature
24	38	InterPro	IPR001034	DeoR-type HTH domain
38	56	PRINTS	PR00037	LacR bacterial regulatory protein HTH signature
38	56	InterPro	IPR001034	DeoR-type HTH domain
2	60	Gene3D	G3DSA:1.10.10.10	-
2	60	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily
6	61	Pfam	PF08220	DeoR-like helix-turn-helix domain
6	61	InterPro	IPR001034	DeoR-type HTH domain
2	57	FunFam	G3DSA:1.10.10.10:FF:000081	DeoR/GlpR family transcriptional regulator
75	231	Pfam	PF00455	DeoR C terminal sensor domain
75	231	InterPro	IPR014036	DeoR C-terminal sensor domain
72	232	SMART	SM01134	DeoRC_2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3583	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.561
2				0.442

PA3583