Protein profile

PA3595

major facilitator superfamily transporter

Genome: NC_002516.2

Gene: PA3595 Structure source: AlphaFold UniProt Q9HY31
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Amino acids 469
Annotations 4
Features 47
PDB binders 0
Druggability 0.69

Overview

Basic information about this protein and its source genome.

Accession
PA3595
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3595
Status
annotated
Amino acids
469
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.69
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPRTPSPEDADLHKKARRAGIASFIGTTIEWYDFYIYGLAAALVFGKVFFPADMDPGLATLLSFVTLWSGFIARPLGGIIFGHLGDRIGRKTTLVITLIMMGIATTCIGLLPVYTQIGIWAPISLVALRIVQGIAVGGEWGGAILIASESAPKGKGILYAAFAQQGSPTGNLLATLAFFALSALPASDFILWGWRAPFLLSAVLVIVGMVIRLKLEESEDMKRVLAQKRTVKLPLAEVLGKHWKIVLLGAGVLPIIHVTYFKSTFALSWATKTLGYSQGTFLSIIVVALVVQFLSQPLGALLTSRIDMRKAACLMVLPEFILMPAMFFAVETKVYWIAAVGMCLATVPHAMFYGAVGGILARAFPARVRYTGLSLAYQLCSLLVGGGTPVLAQWILNSTGSIVGVALASACYALVSLACTLALLRITGFHASDLSTAERADAEDLQRPVAVEREPVLRAPARLLGGDPG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

47 records
Show feature table
Start End DB Term Name
214 241 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
362 372 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
402 424 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
192 213 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
58 80 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
19 428 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
19 428 InterPro IPR020846 Major facilitator superfamily domain
17 421 CDD cd17369 MFS_ShiA_like
311 330 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
335 357 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
303 310 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
57 81 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
17 450 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
17 450 InterPro IPR036259 MFS transporter superfamily
242 261 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
281 302 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
126 147 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
282 304 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
82 92 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
159 181 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
370 392 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
191 213 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
373 396 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
397 401 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
402 424 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 428 PANTHER PTHR43045 SHIKIMATE TRANSPORTER
46 56 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
148 167 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
115 125 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
93 115 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
425 469 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
311 330 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
125 147 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
168 186 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
331 335 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
245 267 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
93 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
262 280 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 426 SUPERFAMILY SSF103473 MFS general substrate transporter
6 426 InterPro IPR036259 MFS transporter superfamily
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
21 45 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
187 191 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 218 Pfam PF00083 Sugar (and other) transporter
21 218 InterPro IPR005828 Major facilitator, sugar transporter-like
336 361 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3595
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.69
1 0.53