Protein profile

PA3599

transcriptional regulator

Genome: NC_002516.2

Gene: PA3599 Structure source: AlphaFold UniProt Q9HY27
Export view
Amino acids 261
Annotations 3
Features 21
PDB binders 0
Druggability 0.823

Overview

Basic information about this protein and its source genome.

Accession
PA3599
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3599
Status
annotated
Amino acids
261
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.823
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
216 243 ProSitePatterns PS00622 LuxR-type HTH domain signature.
216 243 InterPro IPR000792 Transcription regulator LuxR, C-terminal
177 260 Gene3D G3DSA:1.10.10.10 -
177 260 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
232 244 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
232 244 InterPro IPR000792 Transcription regulator LuxR, C-terminal
202 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
202 216 InterPro IPR000792 Transcription regulator LuxR, C-terminal
216 232 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
216 232 InterPro IPR000792 Transcription regulator LuxR, C-terminal
27 259 PANTHER PTHR44688 -
196 258 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
196 258 InterPro IPR016032 Signal transduction response regulator, C-terminal effector
195 260 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
195 260 InterPro IPR000792 Transcription regulator LuxR, C-terminal
201 252 Pfam PF00196 Bacterial regulatory proteins, luxR family
201 252 InterPro IPR000792 Transcription regulator LuxR, C-terminal
202 253 CDD cd06170 LuxR_C_like
202 253 InterPro IPR000792 Transcription regulator LuxR, C-terminal
199 256 SMART SM00421 luxrmega5
199 256 InterPro IPR000792 Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3599
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.823
3 0.228