Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3601
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3601 rpmE2
Status: annotated
Amino acids: 87
Structure source: AlphaFold

GO

GO:1990904 A macromolecular complex that contains both RNA and protein molecules. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.326

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:1990904 A macromolecular complex that contains both RNA and protein molecules.
GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
2	19	PRINTS	PR01249	Ribosomal protein L31 signature
2	19	InterPro	IPR002150	Ribosomal protein L31
45	60	PRINTS	PR01249	Ribosomal protein L31 signature
45	60	InterPro	IPR002150	Ribosomal protein L31
60	78	PRINTS	PR01249	Ribosomal protein L31 signature
60	78	InterPro	IPR002150	Ribosomal protein L31
1	81	Hamap	MF_00502	50S ribosomal protein L31 type B [rpmE2].
1	81	InterPro	IPR027493	Ribosomal protein L31 type B
49	70	ProSitePatterns	PS01143	Ribosomal protein L31 signature.
49	70	InterPro	IPR002150	Ribosomal protein L31
1	81	Gene3D	G3DSA:4.10.830.30	Ribosomal protein L31
1	81	InterPro	IPR042105	Ribosomal protein L31 superfamily
1	79	Pfam	PF01197	Ribosomal protein L31
1	79	InterPro	IPR002150	Ribosomal protein L31
1	81	SUPERFAMILY	SSF143800	L28p-like
1	81	InterPro	IPR034704	L28p-like
1	80	NCBIfam	TIGR00105	50S ribosomal protein L31
1	80	InterPro	IPR002150	Ribosomal protein L31
2	80	PANTHER	PTHR33280	50S RIBOSOMAL PROTEIN L31, CHLOROPLASTIC
2	80	InterPro	IPR002150	Ribosomal protein L31

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3601	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.326

PA3601