Protein profile

PA3602

hypothetical protein

Genome: NC_002516.2

Gene: PA3602 Structure source: AlphaFold UniProt Q9HY24
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Amino acids 536
Annotations 4
Features 20
PDB binders 4
Druggability 0.355

Overview

Basic information about this protein and its source genome.

Accession
PA3602
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3602
Status
annotated
Amino acids
536
Structure source
AlphaFold
GO
GO:0015930 Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. GO:0019676 The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen. GO:0006537 OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. GO:0016638 Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.355
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0015930 Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors.
  • GO:0019676 The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
  • GO:0006537 OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.
  • GO:0016638 Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
69 489 CDD cd02808 GltS_FMN
69 489 InterPro IPR002932 Glutamate synthase domain
146 505 FunFam G3DSA:3.20.20.70:FF:000156 Glutamate synthase domain protein
6 502 SUPERFAMILY SSF51395 FMN-linked oxidoreductases
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 532 PIRSF PIRSF500060 UCP500060
12 532 InterPro IPR027283 Glutamate synthase large subunit-like protein, bacteria
1 8 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
150 505 Gene3D G3DSA:3.20.20.70 Aldolase class I
150 505 InterPro IPR013785 Aldolase-type TIM barrel
158 475 Pfam PF01645 Conserved region in glutamate synthase
158 475 InterPro IPR002932 Glutamate synthase domain
8 535 PIRSF PIRSF006429 GOGAT_lg_2
8 535 InterPro IPR024188 Glutamate synthase large subunit-like protein
52 536 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
52 490 PANTHER PTHR43819 ARCHAEAL-TYPE GLUTAMATE SYNTHASE [NADPH]
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
32 51 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 31 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
9 26 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3602
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.355
3 0.287

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

30 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AKG
1LLW
P55038 146.1 Da LogP -0.50 TPSA 91.7 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)C(=O)O
F3S
1LLW
P55038 295.8 Da LogP 2.59 TPSA 0.0 ✓ Ro5 ✓ Clean S1[Fe]2S[Fe]3[S]2[Fe]1S3
OMT
1EA0
Q05755 181.2 Da LogP -1.17 TPSA 97.5 ✓ Ro5 ✓ Clean CS(=O)(=O)CC[C@@H](C(=O)O)N
ONL
1OFE
P55038 145.2 Da LogP -0.23 TPSA 80.4 ✓ Ro5 ✓ Clean CC(=O)CC[C@@H](C(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.