Protein profile

PA3626

tRNA pseudouridine synthase D

Genome: NC_002516.2

Gene: truD PA3626 Structure source: AlphaFold UniProt Q9HY04
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Amino acids 355
Annotations 8
Features 18
PDB binders 0
Druggability 0.605

Overview

Basic information about this protein and its source genome.

Accession
PA3626
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
truD PA3626
Status
annotated
Amino acids
355
Structure source
AlphaFold
EC
5.4.99.27
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009982 Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0160150 Catalysis of the reaction: uridine(13) in tRNA = pseudouridine(13) in tRNA. GO:0001522 The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0031119 The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.605
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0009982 Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0160150 Catalysis of the reaction: uridine(13) in tRNA = pseudouridine(13) in tRNA.
  • GO:0001522 The intramolecular conversion of uridine to pseudouridine within an RNA molecule.
  • GO:0031119 The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.
  • GO:0009451 The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
9 345 Hamap MF_01082 tRNA pseudouridine synthase D [truD].
9 345 InterPro IPR001656 Pseudouridine synthase, TruD
7 350 PANTHER PTHR47811 TRNA PSEUDOURIDINE SYNTHASE D
81 94 ProSitePatterns PS01268 Uncharacterized protein family UPF0024 signature.
81 94 InterPro IPR020119 Pseudouridine synthase TruD, conserved site
160 306 ProSiteProfiles PS50984 TRUD domain profile.
160 306 InterPro IPR011760 Pseudouridine synthase, TruD, insertion domain
21 340 Gene3D G3DSA:3.30.2350.20 TruD, catalytic domain
21 340 InterPro IPR042214 Pseudouridine synthase, TruD, catalytic domain
172 304 Gene3D G3DSA:3.30.2340.10 TruD, insertion domain
172 304 InterPro IPR043165 Pseudouridine synthase, TruD, insertion domain superfamily
22 341 CDD cd02575 PseudoU_synth_EcTruD
13 342 SUPERFAMILY SSF55120 Pseudouridine synthase
13 342 InterPro IPR020103 Pseudouridine synthase, catalytic domain superfamily
23 172 Pfam PF01142 tRNA pseudouridine synthase D (TruD)
23 172 InterPro IPR001656 Pseudouridine synthase, TruD
189 340 Pfam PF01142 tRNA pseudouridine synthase D (TruD)
189 340 InterPro IPR001656 Pseudouridine synthase, TruD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3626
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.605
3 0.216