Protein profile

PA3643

lipid-A-disaccharide synthase

Genome: NC_002516.2

Gene: PA3643 lpxB Structure source: AlphaFold UniProt Q9HXY8
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Amino acids 378
Annotations 5
Features 11
PDB binders 0
Druggability 0.784

Overview

Basic information about this protein and its source genome.

Accession
PA3643
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3643 lpxB
Status
annotated
Amino acids
378
Structure source
AlphaFold
EC
2.4.1.182
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008915 Catalysis of the reaction: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + UDP + H+. GO:0005543 Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. GO:0009245 The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.784
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008915 Catalysis of the reaction: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + UDP + H+.
  • GO:0005543 Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
  • GO:0009245 The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
4 376 InterPro IPR003835 Glycosyl transferase, family 19
170 371 FunFam G3DSA:3.40.50.2000:FF:000245 Lipid-A-disaccharide synthase
5 377 PANTHER PTHR30372 LIPID-A-DISACCHARIDE SYNTHASE
5 377 InterPro IPR003835 Glycosyl transferase, family 19
6 375 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
7 360 Pfam PF02684 Lipid-A-disaccharide synthetase
7 360 InterPro IPR003835 Glycosyl transferase, family 19
6 374 NCBIfam TIGR00215 lipid-A-disaccharide synthase
6 374 InterPro IPR003835 Glycosyl transferase, family 19
170 371 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
4 376 Hamap MF_00392 Lipid-A-disaccharide synthase [lpxB].

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3643
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.784