Protein profile

PA3649

zinc metalloprotease

Genome: NC_002516.2

Gene: PA3649 mucP DT376_05790 IPC1295_18770 CAZ10_16915 Structure source: Experimental + AlphaFold UniProt Q9HXY3 UniProt A5JIY6
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Amino acids 450
Annotations 8
Features 40
PDB binders 0
Druggability 0.903

Overview

Basic information about this protein and its source genome.

Accession
PA3649
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3649 mucP DT376_05790 IPC1295_18770 CAZ10_16915
Status
annotated
Amino acids
450
Structure source
Experimental + AlphaFold
EC
3.4.24.-
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004175 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0046872 Binding to a metal ion. GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.903
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004175 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
  • GO:0046872 Binding to a metal ion.
  • GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records
Show feature table
Start End DB Term Name
97 122 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
2 450 NCBIfam TIGR00054 RIP metalloprotease RseP
2 450 InterPro IPR004387 Peptidase M50, putative membrane-associated zinc metallopeptidase
224 436 Pfam PF02163 Peptidase family M50
224 436 InterPro IPR008915 Peptidase M50
10 193 Pfam PF02163 Peptidase family M50
10 193 InterPro IPR008915 Peptidase M50
97 119 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
87 181 SUPERFAMILY SSF50156 PDZ domain-like
87 181 InterPro IPR036034 PDZ superfamily
129 161 Pfam PF17820 PDZ domain
129 161 InterPro IPR041489 PDZ domain 6
111 195 CDD cd00989 PDZ_metalloprotease
221 306 Gene3D G3DSA:2.30.42.10 -
221 306 InterPro IPR036034 PDZ superfamily
123 381 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
225 289 Pfam PF13180 PDZ domain
225 289 InterPro IPR001478 PDZ domain
445 450 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
216 450 PANTHER PTHR42837 REGULATOR OF SIGMA-E PROTEASE RSEP
216 450 InterPro IPR004387 Peptidase M50, putative membrane-associated zinc metallopeptidase
4 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
425 444 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 121 CDD cd06163 S2P-M50_PDZ_RseP-like
208 290 SUPERFAMILY SSF50156 PDZ domain-like
208 290 InterPro IPR036034 PDZ superfamily
379 449 CDD cd06163 S2P-M50_PDZ_RseP-like
29 96 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
423 444 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
125 220 Gene3D G3DSA:2.30.42.10 -
125 220 InterPro IPR036034 PDZ superfamily
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
114 186 SMART SM00228 pdz_new
114 186 InterPro IPR001478 PDZ domain
211 280 SMART SM00228 pdz_new
211 280 InterPro IPR001478 PDZ domain
6 28 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
211 287 CDD cd00989 PDZ_metalloprotease
412 422 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
382 411 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

3 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7XFS
X-ray 1.06 Å A,B
21.1% 126-220
PDBe RCSB PDBj File
Viewing
PDB 7XFT
X-ray 1.21 Å A
19.6% 222-309
PDBe RCSB PDBj File
Loaded
PDB 7XFU
X-ray 1.53 Å A,B
19.6% 222-309
PDBe RCSB PDBj File
Loaded
AlphaFold PA3649
AlphaFold — — full sequence — Loaded
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