Protein profile

PA3652

ditrans,polycis-undecaprenyl-diphosphate synthase

Genome: NC_002516.2

Gene: uppS PA3652 Structure source: AlphaFold UniProt Q9HXY2
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Amino acids 251
Annotations 9
Features 16
PDB binders 5
Druggability 0.737

Overview

Basic information about this protein and its source genome.

Accession
PA3652
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
uppS PA3652
Status
annotated
Amino acids
251
Structure source
AlphaFold
EC
2.5.1.31
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008834 Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate. GO:0000287 Binding to a magnesium (Mg) ion. GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0016094 The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
46.552
Human E-value
9.21e-10
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.737
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MEKTRKDVCVPRHVAIIMDGNNRWAKKRLLPGVAGHKAGVDAVRAVIEVCAEAGVEVLTLFAFSSENWQRPADEVSALMELFLVALRREVRKLDENGIRLRIIGDRTRFHPELQAAMREAEAATAGNTRFLLQVAANYGGQWDIVQAAQRLAREVQGGHLAADDISAELLQGCLVTGDQPLPDLCIRTGGEHRISNFLLWQLAYAELYFSDLFWPDFKHAAMRAALADFSKRQRRFGKTSEQVEAEARPSC

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008834 Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0071555 A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
  • GO:0009252 The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides.
  • GO:0016094 The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans.
  • GO:0008360 Any process that modulates the surface configuration of a cell.
  • GO:0016765 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
10 238 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS].
10 238 InterPro IPR001441 Decaprenyl diphosphate synthase-like
17 237 Pfam PF01255 Putative undecaprenyl diphosphate synthase
17 237 InterPro IPR001441 Decaprenyl diphosphate synthase-like
10 233 SUPERFAMILY SSF64005 Undecaprenyl diphosphate synthase
10 233 InterPro IPR036424 Decaprenyl diphosphate synthase-like superfamily
183 200 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature.
183 200 InterPro IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site
10 237 NCBIfam TIGR00055 polyprenyl diphosphate synthase
10 237 InterPro IPR001441 Decaprenyl diphosphate synthase-like
10 238 PANTHER PTHR10291 DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER
13 231 CDD cd00475 Cis_IPPS
13 231 InterPro IPR001441 Decaprenyl diphosphate synthase-like
1 239 FunFam G3DSA:3.40.1180.10:FF:000001 (2E,6E)-farnesyl-diphosphate-specific ditrans,polycis-undecaprenyl-diphosphate synthase
1 239 Gene3D G3DSA:3.40.1180.10 -
1 239 InterPro IPR036424 Decaprenyl diphosphate synthase-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3652
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.737

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

72 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
53Q
7JLJ
O31751 406.0 Da LogP 6.56 TPSA 12.5 1 viol. ✓ Clean CCN(CC)CCOc1ccc(cc1)/C(=C(\c2ccccc2)/Cl)/c3cccc…
FPP
4H8E
P60477 382.3 Da LogP 4.63 TPSA 113.3 ✓ Ro5 ✓ Clean CC(=CCC/C(=C/CC/C(=C/CO[P@@](=O)(O)OP(=O)(O)O)/…
FPS
4U82
P60477 398.4 Da LogP 5.35 TPSA 104.1 1 viol. ✓ Clean CC(=CCC/C(=C/CC/C(=C/CS[P@@](=O)(O)OP(=O)(O)O)/…
H78
3WYJ
P60472 948.7 Da LogP 3.71 TPSA 362.9 2 viol. ✓ Clean c1cc(cc(c1)c2cccc(c2)NS(=O)(=O)c3cccc(c3)S(=O)(…
V0D
7JLR
O31751 338.4 Da LogP 4.48 TPSA 33.4 ✓ Ro5 ✓ Clean CCc1cc(n2c(n1)c(cn2)c3ccc(cc3)F)N4CCCCCC4

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.