Protein profile

PA3653

ribosome recycling factor

Genome: NC_002516.2

Gene: PA3653 frr Structure source: AlphaFold UniProt O82853
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Amino acids 185
Annotations 5
Features 17
PDB binders 1
Druggability 0.772

Overview

Basic information about this protein and its source genome.

Accession
PA3653
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3653 frr
Status
annotated
Amino acids
185
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043023 Binding to a large ribosomal subunit. GO:0002184 The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
29.05
Human E-value
8.45e-18
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.772
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0043023 Binding to a large ribosomal subunit.
  • GO:0002184 The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.
  • GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
96 182 FunFam G3DSA:1.10.132.20:FF:000001 Ribosome-recycling factor
22 183 Pfam PF01765 Ribosome recycling factor
22 183 InterPro IPR023584 Ribosome recycling factor domain
125 159 Coils Coil Coil
5 183 CDD cd00520 RRF
5 183 InterPro IPR002661 Ribosome recycling factor
1 185 SUPERFAMILY SSF55194 Ribosome recycling factor, RRF
1 185 InterPro IPR036191 RRF superfamily
5 183 PANTHER PTHR20982 RIBOSOME RECYCLING FACTOR
31 105 Gene3D G3DSA:3.30.1360.40 -
12 182 Gene3D G3DSA:1.10.132.20 -
12 182 InterPro IPR036191 RRF superfamily
31 105 FunFam G3DSA:3.30.1360.40:FF:000001 Ribosome-recycling factor
3 185 Hamap MF_00040 Ribosome-recycling factor [frr].
3 185 InterPro IPR002661 Ribosome recycling factor
10 185 NCBIfam TIGR00496 ribosome recycling factor
10 185 InterPro IPR002661 Ribosome recycling factor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3653
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.772
2 0.418

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
DEM
1EK8
P0A805 188.3 Da LogP 3.09 TPSA 29.5 ✓ Ro5 ✓ Clean CCCCCCCCCCOCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.