Protein profile

PA3654

uridylate kinase

Genome: NC_002516.2

Gene: PA3654 pyrH Structure source: AlphaFold UniProt O82852
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Amino acids 245
Annotations 9
Features 16
PDB binders 1
Druggability 0.525

Overview

Basic information about this protein and its source genome.

Accession
PA3654
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3654 pyrH
Status
annotated
Amino acids
245
Structure source
AlphaFold
EC
2.7.4.22
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0033862 Catalysis of the reaction: ATP + UMP = ADP + UDP. GO:0044210 The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. GO:0006225 The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate. GO:0006221 The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.525
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0033862 Catalysis of the reaction: ATP + UMP = ADP + UDP.
  • GO:0044210 The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.
  • GO:0006225 The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate.
  • GO:0006221 The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0009041 OBSOLETE. Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
13 243 CDD cd04254 AAK_UMPK-PyrH-Ec
13 243 InterPro IPR015963 Uridylate kinase, bacteria
6 245 FunFam G3DSA:3.40.1160.10:FF:000001 Uridylate kinase
10 243 Hamap MF_01220_B Uridylate kinase [pyrH].
10 243 InterPro IPR015963 Uridylate kinase, bacteria
12 243 NCBIfam TIGR02075 UMP kinase
12 243 InterPro IPR015963 Uridylate kinase, bacteria
7 245 PIRSF PIRSF005650 Uridylate_kin
7 245 InterPro IPR011817 Uridylate kinase
2 245 Gene3D G3DSA:3.40.1160.10 -
2 245 InterPro IPR036393 Acetylglutamate kinase-like superfamily
10 242 SUPERFAMILY SSF53633 Carbamate kinase-like
10 242 InterPro IPR036393 Acetylglutamate kinase-like superfamily
6 244 PANTHER PTHR42833 URIDYLATE KINASE
13 222 Pfam PF00696 Amino acid kinase family
13 222 InterPro IPR001048 Aspartate/glutamate/uridylate kinase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3654
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.525
6 0.258

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
ANP
2BRI
Q8U122 506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.