Protein profile

PA3655

elongation factor Ts

Genome: NC_002516.2

Gene: tsf PA3655 Structure source: AlphaFold UniProt O82851
Export view
Amino acids 289
Annotations 4
Features 26
PDB binders 0
Druggability 0.467

Overview

Basic information about this protein and its source genome.

Accession
PA3655
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
tsf PA3655
Status
annotated
Amino acids
289
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003746 Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0006414 The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
34.066
Human E-value
6e-08
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.467
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0003746 Functions in chain elongation during polypeptide synthesis at the ribosome.
  • GO:0006414 The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
184 231 FunFam G3DSA:1.10.286.20:FF:000001 Elongation factor Ts
12 27 ProSitePatterns PS01126 Elongation factor Ts signature 1.
12 27 InterPro IPR018101 Translation elongation factor Ts, conserved site
184 232 Gene3D G3DSA:1.10.286.20 -
148 266 Gene3D G3DSA:3.30.479.20 Elongation factor Ts, dimerisation domain
148 266 InterPro IPR036402 Elongation factor Ts, dimerisation domain superfamily
5 275 PANTHER PTHR11741 ELONGATION FACTOR TS
5 275 InterPro IPR001816 Translation elongation factor EFTs/EF1B
7 42 CDD cd14275 UBA_EF-Ts
56 141 SUPERFAMILY SSF54713 Elongation factor Ts (EF-Ts), dimerisation domain
56 141 InterPro IPR036402 Elongation factor Ts, dimerisation domain superfamily
143 284 SUPERFAMILY SSF54713 Elongation factor Ts (EF-Ts), dimerisation domain
143 284 InterPro IPR036402 Elongation factor Ts, dimerisation domain superfamily
1 55 Gene3D G3DSA:1.10.8.10 -
1 284 Hamap MF_00050 Elongation factor Ts [tsf].
1 284 InterPro IPR001816 Translation elongation factor EFTs/EF1B
1 56 FunFam G3DSA:1.10.8.10:FF:000001 Elongation factor Ts
1 284 NCBIfam TIGR00116 translation elongation factor Ts
77 87 ProSitePatterns PS01127 Elongation factor Ts signature 2.
77 87 InterPro IPR018101 Translation elongation factor Ts, conserved site
56 143 Gene3D G3DSA:3.30.479.20 Elongation factor Ts, dimerisation domain
56 143 InterPro IPR036402 Elongation factor Ts, dimerisation domain superfamily
3 56 SUPERFAMILY SSF46934 UBA-like
3 56 InterPro IPR009060 UBA-like superfamily
73 267 Pfam PF00889 Elongation factor TS
73 267 InterPro IPR014039 Translation elongation factor EFTs/EF1B, dimerisation

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3655
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.467
1 0.412