Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3658
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3658 glnD
Status: annotated
Amino acids: 900
Structure source: AlphaFold

GO

GO:0008773 Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). GO:0008081 Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006808 Any process that modulates the frequency, rate or extent of nitrogen utilization. GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.563

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MPQVDPELFDRGQFQAELALKSSPIAAFKKAIRQFREVLDNRFNSGRDIRRLIEDRAWCVDQILQQAWQRFDWGDDADIALVAVGGYGRGELHPYSDVDLLILLDSEDQESFREPIEGFLTLLWDIGLEVGQSVRSVQQCAEEARADLTVITTLMECRTICGPDSLRQRMLQVTGSAHMWPSKEFFLAKRHEQQRRHAKYNDTEYNLEPNVKGSPGGLRDIQTILWMARRQFGSLNLHALVREGFLVESECSMLASSQEFLWRVRYALHMLAGRAEDRLLFDHQRSIARLFGYEDNDVKLAVERFMQKYYRVVMAISELNDLIIQHFEEVILPCEQPVQIQPLNSRFQLRDGYIEVTHPNVFKRTPFALLEIFVLMAQHPEIKGVRADTIRLLRDSRHLIDDEFRHDIRNTSLFIELFKSSQGIHRNLRRMNRYGILGRYLPEFGHIIGQMQHDLFHIYTVDAHTLNLIKHLRKLNRPEMAEKYPLASKIIDRLPKPELIYIAGLYHDIAKGRGGDHSELGAVDAEAFCQSHQLPLWDTQLVSWLVQNHLVMSTTAQRKDLSDPQVIFDFAQLVGDQTHLDYLYVLTVADINATNPTLWNSWRASLLRQLYTETKRALRRGLENPVDREEQIRQTQTAALDQLVRNGIDQDDAEQLWSQLGDDYFLRHTAGDVAWHTEAILQHPDDGTPLVLIKETTQREFESGSQIFIYAADQHDFFAVTVAAMDQLNLSIQDARIITSTSQFTLDTYIVLDADGDSIGNNPERIAEIREGLIDALKNPDDYPTIIQRRVPRQLKHFAFAPQVTISTDALRQVSVLEVIAPDRPGLLARIGGIFLDFDLSVQNAKIATLGERVEDVFYITDARNQPLADPDLCKRLQAALVEQLSQDNGRDTLPTRINF

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0008773 Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII).
GO:0008081 Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
GO:0006808 Any process that modulates the frequency, rate or extent of nitrogen utilization.
GO:0016779 Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
GO:0006807 OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

Sequence Features

Domain/signature hits from InterPro and related databases.

40 records

Show feature table

Start	End	DB	Term	Name
457	604	SMART	SM00471	hd_13
457	604	InterPro	IPR003607	HD/PDEase domain
816	891	ProSiteProfiles	PS51671	ACT domain profile.
816	891	InterPro	IPR002912	ACT domain
185	322	Pfam	PF08335	GlnD PII-uridylyltransferase
185	322	InterPro	IPR013546	PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
205	314	SUPERFAMILY	SSF81593	Nucleotidyltransferase substrate binding subunit/domain
12	892	PIRSF	PIRSF006288	PII_uridyltransf
12	892	InterPro	IPR010043	Bifunctional uridylyltransferase/uridylyl-removing enzyme
29	172	CDD	cd05401	NT_GlnE_GlnD_like
8	181	SUPERFAMILY	SSF81301	Nucleotidyltransferase
8	181	InterPro	IPR043519	Nucleotidyltransferase superfamily
384	614	FunFam	G3DSA:1.10.3090.10:FF:000005	Bifunctional uridylyltransferase/uridylyl-removing enzyme
815	885	CDD	cd04899	ACT_ACR-UUR-like_2
426	591	SUPERFAMILY	SSF109604	HD-domain/PDEase-like
459	611	CDD	cd00077	HDc
459	611	InterPro	IPR003607	HD/PDEase domain
816	874	Pfam	PF01842	ACT domain
816	874	InterPro	IPR002912	ACT domain
23	890	PANTHER	PTHR47320	BIFUNCTIONAL URIDYLYLTRANSFERASE/URIDYLYL-REMOVING ENZYME
23	890	InterPro	IPR010043	Bifunctional uridylyltransferase/uridylyl-removing enzyme
463	567	Pfam	PF01966	HD domain
463	567	InterPro	IPR006674	HD domain
72	114	Pfam	PF01909	Nucleotidyltransferase domain
72	114	InterPro	IPR002934	Polymerase, nucleotidyl transferase domain
704	777	CDD	cd04900	ACT_UUR-like_1
706	789	ProSiteProfiles	PS51671	ACT domain profile.
706	789	InterPro	IPR002912	ACT domain
461	583	ProSiteProfiles	PS51831	HD domain profile.
461	583	InterPro	IPR006674	HD domain
36	885	NCBIfam	TIGR01693	[protein-PII] uridylyltransferase
36	885	InterPro	IPR010043	Bifunctional uridylyltransferase/uridylyl-removing enzyme
187	326	Gene3D	G3DSA:1.20.120.330	Nucleotidyltransferases domain 2
813	879	SUPERFAMILY	SSF55021	ACT-like
813	879	InterPro	IPR045865	ACT-like domain
1	897	Hamap	MF_00277	Bifunctional uridylyltransferase/uridylyl-removing enzyme [glnD].
1	897	InterPro	IPR010043	Bifunctional uridylyltransferase/uridylyl-removing enzyme
53	172	Gene3D	G3DSA:3.30.460.10	Beta Polymerase, domain 2
53	172	InterPro	IPR043519	Nucleotidyltransferase superfamily
385	659	Gene3D	G3DSA:1.10.3090.10	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3658	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.226
1				0.202

PA3658