Protein profile

PA3673

glycerol-3-phosphate acyltransferase

Genome: NC_002516.2

Gene: PA3673 plsB Structure source: AlphaFold UniProt Q9HXW7
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Amino acids 834
Annotations 9
Features 20
PDB binders 0
Druggability 0.876

Overview

Basic information about this protein and its source genome.

Accession
PA3673
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3673 plsB
Status
annotated
Amino acids
834
Structure source
AlphaFold
EC
2.3.1.15
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004366 Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA. GO:0016024 The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. GO:0006631 The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
40.0
Human E-value
4.54e-35
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.876
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0004366 Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA.
  • GO:0016024 The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.
  • GO:0006631 The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
  • GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
  • GO:0008374 Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.
  • GO:0044255 OBSOLETE. The chemical reactions and pathways involving lipids, as carried out by individual cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
15 816 Hamap MF_00393 Glycerol-3-phosphate acyltransferase [plsB].
15 816 InterPro IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
21 827 PIRSF PIRSF000437 GPAT_DHAPAT
21 827 InterPro IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
262 523 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
14 812 NCBIfam TIGR03703 glycerol-3-phosphate 1-O-acyltransferase PlsB
14 812 InterPro IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
284 485 CDD cd07993 LPLAT_DHAPAT-like
284 485 InterPro IPR041728 GPAT/DHAPAT, acyltransferase domain
4 829 PIRSF PIRSF500064 GPAT
4 829 InterPro IPR028354 Glycerol-3-phosphate acyltransferase, PlsB
149 789 PANTHER PTHR12563 GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE
149 789 InterPro IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
439 782 Pfam PF19277 Glycerol-3-phosphate acyltransferase C-terminal region
439 782 InterPro IPR045520 GPAT/DHAPAT, C-terminal domain
304 431 SMART SM00563 plsc_2
304 431 InterPro IPR002123 Phospholipid/glycerol acyltransferase
293 428 Pfam PF01553 Acyltransferase
293 428 InterPro IPR002123 Phospholipid/glycerol acyltransferase
1 11 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3673
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.717
6 0.223
12 0.219