Protein profile

PA3677

resistance-nodulation-cell division (RND) efflux membrane fusion protein

Genome: NC_002516.2

Gene: PA3677 Structure source: AlphaFold UniProt Q9HXW3

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Amino acids 367

Annotations 4

Features 22

PDB binders 0

Druggability 0.588

Overview

Basic information about this protein and its source genome.

Accession: PA3677
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3677
Status: annotated
Amino acids: 367
Structure source: AlphaFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.588

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0046677 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
7	19	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
57	199	Gene3D	G3DSA:2.40.50.100	-
263	354	Gene3D	G3DSA:2.40.420.20	-
1	19	SignalP_GRAM_NEGATIVE	SignalP-noTM	SignalP-noTM
136	156	Coils	Coil	Coil
8	356	PANTHER	PTHR30469	MULTIDRUG RESISTANCE PROTEIN MDTA
44	353	NCBIfam	TIGR01730	efflux RND transporter periplasmic adaptor subunit
44	353	InterPro	IPR006143	RND efflux pump, membrane fusion protein
1	21	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
61	262	Pfam	PF16576	Barrel-sandwich domain of CusB or HlyD membrane-fusion
61	262	InterPro	IPR032317	RND efflux pump, membrane fusion protein, barrel-sandwich domain
1	31	Phobius	SIGNAL_PEPTIDE	Signal peptide region
20	31	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
197	261	FunFam	G3DSA:2.40.30.170:FF:000014	Efflux RND transporter periplasmic adaptor subunit
98	125	Coils	Coil	Coil
1	6	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	31	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
32	367	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
92	165	Gene3D	G3DSA:1.10.287.470	Helix hairpin bin
47	276	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
1	24	SignalP_EUK	SignalP-noTM	SignalP-noTM
51	261	Gene3D	G3DSA:2.40.30.170	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3677	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.467
1				0.326
6				0.23