Protein profile

PA3695

hypothetical protein

Genome: NC_002516.2

Gene: PA3695 Structure source: AlphaFold UniProt Q9HXU5
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Amino acids 301
Annotations 2
Features 27
PDB binders 1
Druggability 0.839

Overview

Basic information about this protein and its source genome.

Accession
PA3695
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3695
Status
annotated
Amino acids
301
Structure source
AlphaFold
GO
GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
29.167
Human E-value
4.81e-08
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.839
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records
Show feature table
Start End DB Term Name
98 109 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature
98 109 InterPro IPR002410 Peptidase S33
142 156 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature
142 156 InterPro IPR002410 Peptidase S33
71 79 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature
71 79 InterPro IPR002410 Peptidase S33
1 19 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
4 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
26 276 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
26 276 InterPro IPR029058 Alpha/Beta hydrolase fold
67 171 Pfam PF12146 Serine aminopeptidase, S33
67 171 InterPro IPR022742 Serine aminopeptidase, S33
156 169 PRINTS PR00111 Alpha/beta hydrolase fold signature
156 169 InterPro IPR000073 Alpha/beta hydrolase fold-1
95 110 PRINTS PR00111 Alpha/beta hydrolase fold signature
95 110 InterPro IPR000073 Alpha/beta hydrolase fold-1
142 155 PRINTS PR00111 Alpha/beta hydrolase fold signature
142 155 InterPro IPR000073 Alpha/beta hydrolase fold-1
38 259 PANTHER PTHR12277 ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN
25 277 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
25 277 InterPro IPR029058 Alpha/Beta hydrolase fold
22 301 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3695
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.839
3 0.414

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

74 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
OXE
3E0X
Q97KV0 106.2 Da LogP 2.30 TPSA 0.0 ✓ Ro5 ✓ Clean Cc1ccccc1C

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.