Overview
Basic information about this protein and its source genome.
- Accession
- PA3701
- Gene
- PA3701 prfB
- Status
- annotated
- Amino acids
- 364
- Structure source
- AlphaFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 51.587
- Human E-value
- 4.94e-34
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Cytoplasmic
Selected Druggability evidence
Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
4- GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
- GO:0016149 A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site.
- GO:0006415 The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
- GO:0003747 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 10 | 361 | NCBIfam | TIGR00020 | peptide chain release factor 2 |
| 10 | 361 | InterPro | IPR004374 | Peptide chain release factor 2 |
| 225 | 320 | Gene3D | G3DSA:3.30.160.20 | - |
| 1 | 115 | Gene3D | G3DSA:1.20.58.410 | Release factor |
| 8 | 361 | PANTHER | PTHR43116 | PEPTIDE CHAIN RELEASE FACTOR 2 |
| 227 | 336 | Pfam | PF00472 | RF-1 domain |
| 227 | 336 | InterPro | IPR000352 | Peptide chain release factor class I |
| 3 | 363 | SUPERFAMILY | SSF75620 | Release factor |
| 3 | 363 | InterPro | IPR045853 | Peptide chain release factor class I superfamily |
| 129 | 356 | Gene3D | G3DSA:3.30.70.1660 | - |
| 31 | 219 | Pfam | PF03462 | PCRF domain |
| 31 | 219 | InterPro | IPR005139 | Peptide chain release factor |
| 84 | 194 | SMART | SM00937 | PCRF_a_2 |
| 84 | 194 | InterPro | IPR005139 | Peptide chain release factor |
| 244 | 260 | ProSitePatterns | PS00745 | Prokaryotic-type class I peptide chain release factors signature. |
| 244 | 260 | InterPro | IPR000352 | Peptide chain release factor class I |
| 95 | 115 | Coils | Coil | Coil |
| 2 | 364 | Hamap | MF_00094 | Peptide chain release factor 2 [prfB]. |
| 2 | 364 | InterPro | IPR004374 | Peptide chain release factor 2 |
| 225 | 320 | FunFam | G3DSA:3.30.160.20:FF:000010 | Peptide chain release factor 2 |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
PA3701
|
AlphaFold | — | — | full sequence | — | Viewing |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.217 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| FME | P07012 | 177.2 Da LogP -0.06 TPSA 66.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](C(=O)O)NC=O
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC221146246 | 0.781 | 308.4 Da LogP 0.18 TPSA 95.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@H](CCSC)NC=O)C(=O)O
|
| ZINC4544549 | 0.758 | 439.6 Da LogP 0.41 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCSC)NC=…
|
| ZINC2116511 | 0.686 | 248.3 Da LogP -0.56 TPSA 95.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](C)C(=O)O
|
| ZINC1576667 | 0.649 | 276.4 Da LogP 0.08 TPSA 95.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@H](C(=O)O)C(C)C
|
| ZINC4899576 | 0.625 | 335.4 Da LogP -2.08 TPSA 144.8 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C…
|
| ZINC8076277 | 0.625 | 305.4 Da LogP -0.45 TPSA 121.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](CCCCN)C(=O)O
|
| ZINC5759645 | 0.610 | 361.5 Da LogP -0.03 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C…
|
| ZINC1576194 | 0.595 | 324.4 Da LogP 0.67 TPSA 95.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC=O)C(=O)O
|
| ZINC1576195 | 0.595 | 324.4 Da LogP 0.67 TPSA 95.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC=O)C(=O)O
|
| ZINC1576196 | 0.595 | 324.4 Da LogP 0.67 TPSA 95.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC=O)C(=O)O
|
| ZINC1576197 | 0.595 | 324.4 Da LogP 0.67 TPSA 95.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC=O)C(=O)O
|
| ZINC2516173 | 0.595 | 324.4 Da LogP 0.67 TPSA 95.5 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
|
| ZINC13550236 | 0.581 | 419.5 Da LogP -0.18 TPSA 161.9 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]…
|
| ZINC15721376 | 0.581 | 455.6 Da LogP 0.90 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C…
|
| ZINC4544540 | 0.581 | 455.6 Da LogP 0.90 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCS…
|
| ZINC5768212 | 0.576 | 205.3 Da LogP 0.72 TPSA 66.4 | ✓ Ro5 | ✓ Clean |
CCC(=O)N[C@@H](CCSC)C(=O)O
|
| ZINC5768215 | 0.576 | 205.3 Da LogP 0.72 TPSA 66.4 | ✓ Ro5 | ✓ Clean |
CCC(=O)N[C@H](CCSC)C(=O)O
|
| ZINC37965632 | 0.559 | 205.3 Da LogP 1.44 TPSA 49.3 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NCC(C)C)C(=O)O
|
| ZINC37965633 | 0.559 | 205.3 Da LogP 1.44 TPSA 49.3 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NCC(C)C)C(=O)O
|
| ZINC2121521 | 0.550 | 287.3 Da LogP -0.97 TPSA 124.6 | ✓ Ro5 | Alert |
CSCC[C@H](NC=C1C(=O)NC(=O)NC1=O)C(=O)O
|
| ZINC2121524 | 0.550 | 287.3 Da LogP -0.97 TPSA 124.6 | ✓ Ro5 | Alert |
CSCC[C@@H](NC=C1C(=O)NC(=O)NC1=O)C(=O)O
|
| ZINC142128194 | 0.543 | 221.3 Da LogP -0.31 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@H](C)O)C(=O)O
|
| ZINC1569422 | 0.543 | 206.3 Da LogP -0.73 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC(=O)CN)C(=O)O
|
| ZINC1569524 | 0.543 | 206.3 Da LogP -0.73 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)CN)C(=O)O
|
| ZINC1672830 | 0.543 | 221.3 Da LogP 0.26 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NCCC(=O)O)C(=O)O
|
| ZINC214816170 | 0.543 | 221.3 Da LogP -0.31 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@@H](C)O)C(=O)O
|
| ZINC214816217 | 0.543 | 221.3 Da LogP -0.31 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC(=O)[C@H](C)O)C(=O)O
|
| ZINC3331958 | 0.543 | 241.3 Da LogP 0.13 TPSA 83.5 | ✓ Ro5 | ✓ Clean |
CCS(=O)(=O)N[C@@H](CCSC)C(=O)O
|
| ZINC3331960 | 0.543 | 241.3 Da LogP 0.13 TPSA 83.5 | ✓ Ro5 | ✓ Clean |
CCS(=O)(=O)N[C@H](CCSC)C(=O)O
|
| ZINC41689785 | 0.543 | 219.3 Da LogP 1.83 TPSA 49.3 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NCCC(C)C)C(=O)O
|
| ZINC41689788 | 0.543 | 219.3 Da LogP 1.83 TPSA 49.3 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NCCC(C)C)C(=O)O
|
| ZINC8614599 | 0.543 | 221.3 Da LogP 0.26 TPSA 86.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NCCC(=O)O)C(=O)O
|
| ZINC100716065 | 0.537 | 303.3 Da LogP 0.50 TPSA 101.9 | ✓ Ro5 | Alert |
CSCC[C@H](NC=C1C(=O)OC(C)(C)OC1=O)C(=O)O
|
| ZINC100716069 | 0.537 | 303.3 Da LogP 0.50 TPSA 101.9 | ✓ Ro5 | Alert |
CSCC[C@@H](NC=C1C(=O)OC(C)(C)OC1=O)C(=O)O
|
| ZINC3874395 | 0.532 | 437.6 Da LogP 1.20 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H…
|
| ZINC3874396 | 0.532 | 437.6 Da LogP 1.20 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H]…
|
| ZINC3874397 | 0.532 | 437.6 Da LogP 1.20 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]…
|
| ZINC3874398 | 0.532 | 437.6 Da LogP 1.20 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](…
|
| ZINC4099172 | 0.532 | 437.6 Da LogP 1.20 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]…
|
| ZINC9212385 | 0.532 | 437.6 Da LogP 1.20 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](…
|
| ZINC9212386 | 0.532 | 437.6 Da LogP 1.20 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C…
|
| ZINC9212387 | 0.532 | 437.6 Da LogP 1.20 TPSA 124.6 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](…
|
| ZINC1605258 | 0.528 | 280.4 Da LogP 0.39 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@H](N)CCSC)C(=O)O
|
| ZINC1605259 | 0.528 | 280.4 Da LogP 0.39 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](N)C(=O)N[C@H](CCSC)C(=O)O
|
| ZINC1605260 | 0.528 | 280.4 Da LogP 0.39 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](N)C(=O)N[C@H](CCSC)C(=O)O
|
| ZINC1692507 | 0.528 | 249.3 Da LogP 0.17 TPSA 103.7 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)CCC(=O)O)C(=O)O
|
| ZINC1708198 | 0.528 | 220.3 Da LogP -0.34 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@H](NC(=O)[C@@H](C)N)C(=O)O
|
| ZINC1708199 | 0.528 | 220.3 Da LogP -0.34 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC(=O)[C@H](C)N)C(=O)O
|
| ZINC1708200 | 0.528 | 220.3 Da LogP -0.34 TPSA 92.4 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC(=O)[C@@H](C)N)C(=O)O
|
| ZINC2043758 | 0.528 | 249.3 Da LogP 0.17 TPSA 103.7 | ✓ Ro5 | ✓ Clean |
CSCC[C@@H](NC(=O)CCC(=O)O)C(=O)O
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.