Protein profile

PA3706

biofilm formation methyltransferase WspC

Genome: NC_002516.2

Gene: PA3706 wspC Structure source: AlphaFold UniProt Q9HXT5
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Amino acids 422
Annotations 7
Features 29
PDB binders 0
Druggability 0.897

Overview

Basic information about this protein and its source genome.

Accession
PA3706
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3706 wspC
Status
annotated
Amino acids
422
Structure source
AlphaFold
EC
2.1.1.-
GO
GO:0098561 A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus. GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.897
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0098561 A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus.
  • GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein.
  • GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
  • GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
65 253 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
65 253 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
327 419 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
327 419 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
130 146 PRINTS PR00996 Glutamate methyltransferase family signature
130 146 InterPro IPR000780 MCP methyltransferase, CheR-type
218 241 PRINTS PR00996 Glutamate methyltransferase family signature
218 241 InterPro IPR000780 MCP methyltransferase, CheR-type
58 70 PRINTS PR00996 Glutamate methyltransferase family signature
58 70 InterPro IPR000780 MCP methyltransferase, CheR-type
97 117 PRINTS PR00996 Glutamate methyltransferase family signature
97 117 InterPro IPR000780 MCP methyltransferase, CheR-type
199 213 PRINTS PR00996 Glutamate methyltransferase family signature
199 213 InterPro IPR000780 MCP methyltransferase, CheR-type
1 264 ProSiteProfiles PS50123 CheR-type methyltransferase domain profile.
1 264 InterPro IPR000780 MCP methyltransferase, CheR-type
66 240 Pfam PF01739 CheR methyltransferase, SAM binding domain
66 240 InterPro IPR022642 MCP methyltransferase, CheR-type, SAM-binding domain, C-terminal
289 312 MobiDBLite mobidb-lite consensus disorder prediction
64 251 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
64 251 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
330 415 SUPERFAMILY SSF48452 TPR-like
330 415 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
3 259 SMART SM00138 methyl_trans_3
3 259 InterPro IPR000780 MCP methyltransferase, CheR-type
5 379 PANTHER PTHR24422 CHEMOTAXIS PROTEIN METHYLTRANSFERASE
97 235 CDD cd02440 AdoMet_MTases
354 387 ProSiteProfiles PS50005 TPR repeat profile.
354 387 InterPro IPR019734 Tetratricopeptide repeat

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3706
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.897
3 0.221