Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3708
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3708 wspA
Status: annotated
Amino acids: 542
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.878

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0004888 Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
GO:0006935 The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records

Show feature table

Start	End	DB	Term	Name
191	212	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
24	28	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
213	542	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
301	330	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
301	330	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
378	405	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
378	405	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
407	436	PRINTS	PR00260	Bacterial chemotaxis sensory transducer signature
407	436	InterPro	IPR004090	Chemotaxis methyl-accepting receptor
10	541	PANTHER	PTHR32089	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB
348	505	Pfam	PF00015	Methyl-accepting chemotaxis protein (MCP) signalling domain
348	505	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
213	542	Gene3D	G3DSA:1.10.287.950	-
210	261	Pfam	PF00672	HAMP domain
210	261	InterPro	IPR003660	HAMP domain
233	542	SUPERFAMILY	SSF58104	Methyl-accepting chemotaxis protein (MCP) signaling domain
10	32	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
3	182	Pfam	PF12729	Four helix bundle sensory module for signal transduction
3	182	InterPro	IPR024478	Chemotaxis methyl-accepting receptor HlyB-like, 4HB MCP domain
73	182	CDD	cd19411	MCP2201-like_sensor
73	182	InterPro	IPR047347	Putative sensory transducer protein YvaQ-like, ligand-binding sensor domain
213	265	ProSiteProfiles	PS50885	HAMP domain profile.
213	265	InterPro	IPR003660	HAMP domain
194	216	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
10	23	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	28	Phobius	SIGNAL_PEPTIDE	Signal peptide region
29	190	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
270	506	ProSiteProfiles	PS50111	Bacterial chemotaxis sensory transducers domain profile.
270	506	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
1	9	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
216	260	CDD	cd06225	HAMP
273	541	SMART	SM00283	MA_2
273	541	InterPro	IPR004089	Methyl-accepting chemotaxis protein (MCP) signalling domain
213	265	SMART	SM00304	HAMP_11

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3708	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.878
2				0.565
4				0.297
6				0.22

PA3708