Protein profile

PA3713

spermidine dehydrogenase SpdH

Genome: NC_002516.2

Gene: spdH PA3713 Structure source: Experimental + AlphaFold UniProt Q9HXS8
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Amino acids 620
Annotations 3
Features 12
PDB binders 0
Druggability 0.763

Overview

Basic information about this protein and its source genome.

Accession
PA3713
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
spdH PA3713
Status
annotated
Amino acids
620
Structure source
Experimental + AlphaFold
GO
GO:0046872 Binding to a metal ion. GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.763
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MTISRRDFLNGVALTIAAGLTPAEILRAAPGGRYYPPALTGLRGSHPGAFEVAHQMGWEKKTFDVDHLPIEEEYDLVVVGGGISGLAAAWFYRERHPAARILVIENHDDFGGHAKRNEFQAGGRTILGYGGSESLQSPNALYSEDAKHLLKRLGVELKRFETAFDTDFYPGLGLSRAVFFDKASFGVDKLVSGDPTPMVADEVPRDRLNARSWRAFIGDFPLSREDREALIALYESPRDYLAGKSVEEKETYLAKTSYRDYLLKNVGLSETSVKYFQGRSNDFSALGADALPAADAYAAGFPGFDALGLPQPSEEAQAEMDEPYIYHFPDGNASLARLMVRDLIPAVAPGRGMEDIVMARFDYSKLDLAGHPVRLRLNSTAVSVRNRAGGVDVGYSRAGRLHRVRGKHCVMACYNMMVPYLLRDLSEEQAHALSQNVKFPLVYTKVLLRNWQAWKTLGIHEIYAPTLPYSRIKLDFPVDLGSYRHPRDPRQPIGVHMVYVPTTPNAGMDARTQARVGRSKLYAMSFEQLEKDIRDQLQAMLGPAGFDHRRDITGITVNRWSHGYSYFMNTLYDDEAESEALMELARSKVGNVAIANSDAAWDAYAHAAIDQAVRAVRELG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0046872 Binding to a metal ion.
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
67 441 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain
67 441 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
78 136 Pfam PF13450 NAD(P)-binding Rossmann-like domain
74 164 Gene3D G3DSA:3.50.50.60 -
74 164 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
29 620 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 31 ProSiteProfiles PS51318 Twin arginine translocation (Tat) signal profile.
1 31 InterPro IPR006311 Twin-arginine translocation pathway, signal sequence
22 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

5 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 7D9F
X-ray 1.85 Å A,B
100.0% 1-620
PDBe RCSB PDBj File
Viewing
PDB 7D9I
X-ray 2.10 Å A,B
100.0% 1-620
PDBe RCSB PDBj File
Loaded
PDB 7D9J
X-ray 2.19 Å A,B
100.0% 1-620
PDBe RCSB PDBj File
Loaded
PDB 7D9G
X-ray 2.40 Å A,B
100.0% 1-620
PDBe RCSB PDBj File
Loaded
PDB 7D9H
X-ray 2.31 Å A,B
94.7% 34-620
PDBe RCSB PDBj File
Loaded
AlphaFold PA3713
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.763

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 115.51 0.998
2 5.38 0.255
3 1.81 0.034
4 1.35 0.016
5 1.21 0.011