Protein profile

PA3718

major facilitator superfamily transporter

Genome: NC_002516.2

Gene: PA3718 Structure source: AlphaFold UniProt Q9HXS3
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Amino acids 413
Annotations 4
Features 49
PDB binders 0
Druggability 0.673

Overview

Basic information about this protein and its source genome.

Accession
PA3718
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3718
Status
annotated
Amino acids
413
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.673
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MDSPSTLARPHPQASPRWLAVANVIFAGIAAALHVGKATIALPSLQRSFGGDLAALSWIMSAFPFVGVFGGIAAGLLVRRWGDRRLLTGGLAILGGASLLGASMQDFTWLLATRFVEGLGFLIVVVAAPAVLHRITSETRRSVVFGLWSTFMAGGIALSMLFGPLLADWRADWQLSALLVLVAALLLPLSVPADDGCRAAGVRPAGLGTLLKVPAITLLALGFTTYNLQFFALMTFLPVFLMQRLGVALETAGLIGAAIVAANALGNVAAGFILSRGIRPGALLASTAILMGLTGAAFFHAAMPGLLAIALGFVFSAVAGMLPTTVLATAPLASPAPSLTPLAIGWVMQGNYLGQVIGPLLIGLIVSRFDWSGAIGLMLVAGAAGAVLGFCLLRALDGLPRAIATGSAARPAD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

49 records
Show feature table
Start End DB Term Name
281 303 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
104 108 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
394 413 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
252 274 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
133 143 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
85 103 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 193 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
14 193 InterPro IPR036259 MFS transporter superfamily
242 252 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
168 172 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
25 331 Pfam PF07690 Major Facilitator Superfamily
25 331 InterPro IPR011701 Major facilitator superfamily
79 84 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
18 35 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
213 241 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
109 132 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
57 79 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
371 393 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
86 105 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
20 397 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
20 397 InterPro IPR020846 Major facilitator superfamily domain
10 395 SUPERFAMILY SSF103473 MFS general substrate transporter
10 395 InterPro IPR036259 MFS transporter superfamily
281 301 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
55 78 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 17 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
215 237 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 224 PANTHER PTHR42718 MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC
144 166 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
193 212 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
366 370 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
275 280 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
173 192 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
36 54 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
331 341 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
307 330 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
144 167 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
110 132 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
209 396 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
209 396 InterPro IPR036259 MFS transporter superfamily
307 329 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
342 365 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
253 274 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
302 306 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
342 364 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
374 396 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
171 193 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
24 390 CDD cd06174 MFS

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3718
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.673