Protein profile

PA3737

thiol:disulfide interchange protein DsbC

Genome: NC_002516.2

Gene: PAERUG_P19_London_7_VIM_2_05_10_03409 CAZ10_17360 GUL26_01465 dsbC PA3737 GNQ48_05735 IPC1295_19215 L4V69_09685 Structure source: AlphaFold UniProt O68904 UniProt G3XD17
Export view
Amino acids 242
Annotations 4
Features 25
PDB binders 2
Druggability 0.866

Overview

Basic information about this protein and its source genome.

Accession
PA3737
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PAERUG_P19_London_7_VIM_2_05_10_03409 CAZ10_17360 GUL26_01465 dsbC PA3737 GNQ48_05735 IPC1295_19215 L4V69_09685
Status
annotated
Amino acids
242
Structure source
AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015036 Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. GO:0003756 Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.866
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:0015036 Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
  • GO:0003756 Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
25 86 SUPERFAMILY SSF54423 DsbC/DsbG N-terminal domain-like
25 86 InterPro IPR009094 Disulphide bond isomerase DsbC/G, N-terminal domain superfamily
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
15 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
29 82 Pfam PF10411 Disulfide bond isomerase protein N-terminus
29 82 InterPro IPR018950 Disulphide bond isomerase, DsbC/G, N-terminal
76 239 Gene3D G3DSA:3.40.30.10 Glutaredoxin
96 236 SUPERFAMILY SSF52833 Thioredoxin-like
96 236 InterPro IPR036249 Thioredoxin-like superfamily
86 242 ProSiteProfiles PS51352 Thioredoxin domain profile.
86 242 InterPro IPR013766 Thioredoxin domain
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
6 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
39 237 CDD cd03020 DsbA_DsbC_DsbG
39 237 InterPro IPR033954 Disulphide bond isomerase, DsbC/G
122 140 ProSitePatterns PS00194 Thioredoxin family active site.
122 140 InterPro IPR017937 Thioredoxin, conserved site
1 238 PANTHER PTHR35272 THIOL:DISULFIDE INTERCHANGE PROTEIN DSBC-RELATED
114 237 Pfam PF13098 Thioredoxin-like domain
114 237 InterPro IPR012336 Thioredoxin-like fold
24 75 Gene3D G3DSA:3.10.450.70 -
24 75 InterPro IPR009094 Disulphide bond isomerase DsbC/G, N-terminal domain superfamily
22 242 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3737
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.843
1 0.414
10 0.281
8 0.276

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
BEZ
3GV1
Q5F6V7 122.1 Da LogP 1.38 TPSA 37.3 ✓ Ro5 ✓ Clean c1ccc(cc1)C(=O)O
BU2
4MLY
D0FZX2 90.1 Da LogP -0.25 TPSA 40.5 ✓ Ro5 ✓ Clean C[C@@H](CCO)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.