Protein profile

PA3744

ribosome maturation factor RimM

Genome: NC_002516.2

Gene: rimM PA3744 Structure source: Experimental + AlphaFold UniProt Q9HXQ0
Export view
Amino acids 175
Annotations 5
Features 17
PDB binders 0
Druggability 0.8

Overview

Basic information about this protein and its source genome.

Accession
PA3744
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
rimM PA3744
Status
annotated
Amino acids
175
Structure source
Experimental + AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0043022 Binding to a ribosome. GO:0030490 Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.8
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
  • GO:0043022 Binding to a ribosome.
  • GO:0030490 Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
  • GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
10 92 Pfam PF01782 RimM N-terminal domain
10 92 InterPro IPR002676 RimM, N-terminal
8 174 NCBIfam TIGR02273 ribosome maturation factor RimM
8 174 InterPro IPR011961 16S rRNA processing protein RimM
7 94 SUPERFAMILY SSF50447 Translation proteins
7 94 InterPro IPR009000 Translation protein, beta-barrel domain superfamily
8 175 Hamap MF_00014 Ribosome maturation factor RimM [rimM].
8 175 InterPro IPR011961 16S rRNA processing protein RimM
3 94 Gene3D G3DSA:2.40.30.60 RimM
3 94 InterPro IPR036976 RimM, N-terminal domain superfamily
98 170 Pfam PF05239 PRC-barrel domain
98 170 InterPro IPR027275 PRC-barrel domain
101 175 Gene3D G3DSA:2.30.30.240 -
101 175 SUPERFAMILY SSF50346 PRC-barrel domain
101 175 InterPro IPR011033 PRC-barrel-like superfamily
6 173 PANTHER PTHR33692 RIBOSOME MATURATION FACTOR RIMM
6 173 InterPro IPR011961 16S rRNA processing protein RimM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2F1L
X-ray 2.46 Å A
100.0% 1-175
PDBe RCSB PDBj File
Viewing
AlphaFold PA3744
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.8

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.11 0.008