Protein profile

PA3750

hypothetical protein

Genome: NC_002516.2

Gene: PA3750 Structure source: AlphaFold UniProt Q9HXP4
Export view
Amino acids 249
Annotations 1
Features 13
PDB binders 0
Druggability 0.842

Overview

Basic information about this protein and its source genome.

Accession
PA3750
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3750
Status
annotated
Amino acids
249
Structure source
AlphaFold
GO
GO:0004622 Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.842
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004622 Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
7 25 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
51 239 SUPERFAMILY SSF52266 SGNH hydrolase
23 249 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
52 240 CDD cd01836 FeeA_FeeB_like
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
55 243 Gene3D G3DSA:3.40.50.1110 SGNH hydrolase
55 243 InterPro IPR036514 SGNH hydrolase superfamily
34 245 PANTHER PTHR30383 THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1
58 229 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family
58 229 InterPro IPR013830 SGNH hydrolase-type esterase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3750
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.842