Protein profile

PA3761

N-acetyl-D-glucosamine phosphotransferase system transporter

Genome: NC_002516.2

Gene: PA3761 Structure source: AlphaFold UniProt Q9HXN4
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Amino acids 570
Annotations 9
Features 60
PDB binders 0
Druggability 0.876

Overview

Basic information about this protein and its source genome.

Accession
PA3761
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3761
Status
annotated
Amino acids
570
Structure source
AlphaFold
GO
GO:0019866 The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0015572 Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. GO:0008982 Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0090563 Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.876
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

9 GO

Gene Ontology (GO)

9
  • GO:0019866 The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
  • GO:0015572 Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.
  • GO:0008982 Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
  • GO:0090563 Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
  • GO:0015764 The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0009401 The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records
Show feature table
Start End DB Term Name
337 359 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
74 92 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
383 466 ProSiteProfiles PS51098 PTS_EIIB type-1 domain profile.
383 466 InterPro IPR001996 Phosphotransferase system, IIB component, type 1
134 154 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
285 307 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
93 97 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
280 284 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
360 570 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
262 280 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
73 92 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
50 67 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
360 444 NCBIfam TIGR00826 glucose PTS transporter subunit EIIB
360 444 InterPro IPR001996 Phosphotransferase system, IIB component, type 1
491 570 ProSiteProfiles PS51098 PTS_EIIB type-1 domain profile.
491 570 InterPro IPR001996 Phosphotransferase system, IIB component, type 1
494 567 SUPERFAMILY SSF55604 Glucose permease domain IIB
494 567 InterPro IPR036878 Glucose permease domain IIB
12 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
49 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
314 332 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 303 Pfam PF02378 Phosphotransferase system, EIIC
14 303 InterPro IPR003352 Phosphotransferase system, EIIC
155 231 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12 34 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
384 457 CDD cd00212 PTS_IIB_glc
384 457 InterPro IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site
333 337 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
115 133 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
398 415 ProSitePatterns PS01035 PTS EIIB domains cysteine phosphorylation site signature.
398 415 InterPro IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site
381 461 Gene3D G3DSA:3.30.1360.60 Glucose permease domain IIB
381 461 InterPro IPR036878 Glucose permease domain IIB
490 569 Gene3D G3DSA:3.30.1360.60 Glucose permease domain IIB
490 569 InterPro IPR036878 Glucose permease domain IIB
285 307 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
3 371 ProSiteProfiles PS51103 PTS_EIIC type-1 domain profile.
3 371 InterPro IPR013013 Phosphotransferase system, EIIC component, type 1
96 113 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 461 PANTHER PTHR30009 CYTOCHROME C-TYPE SYNTHESIS PROTEIN AND PTS TRANSMEMBRANE COMPONENT
31 49 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
232 249 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
98 114 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 457 NCBIfam TIGR01998 N-acetylglucosamine-specific PTS transporter subunit IIBC
7 457 InterPro IPR010974 Phosphotransferase system, N-acetylglucosamine-specific IIBC component
251 261 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
389 419 Pfam PF00367 phosphotransferase system, EIIB
389 419 InterPro IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site
68 73 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
262 279 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
232 250 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
314 332 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
338 359 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
134 156 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
385 459 SUPERFAMILY SSF55604 Glucose permease domain IIB
385 459 InterPro IPR036878 Glucose permease domain IIB
166 188 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
308 313 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
195 217 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3761
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.876
3 0.791