Protein profile

PA3773

hypothetical protein

Genome: NC_002516.2

Gene: PA3773 Structure source: AlphaFold UniProt Q9HXM2
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Amino acids 385
Annotations 3
Features 49
PDB binders 0
Druggability 0.94

Overview

Basic information about this protein and its source genome.

Accession
PA3773
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3773
Status
annotated
Amino acids
385
Structure source
AlphaFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.94
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

49 records
Show feature table
Start End DB Term Name
1 17 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
336 355 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
276 295 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 42 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
111 129 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
276 298 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 43 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
296 300 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
13 383 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
13 383 InterPro IPR036259 MFS transporter superfamily
301 323 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 325 Pfam PF07690 Major Facilitator Superfamily
32 325 InterPro IPR011701 Major facilitator superfamily
79 84 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
212 237 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
106 110 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
210 232 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
383 385 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
167 191 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
18 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
361 382 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
249 269 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
162 166 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 381 PANTHER PTHR43124 PURINE EFFLUX PUMP PBUE
18 385 SUPERFAMILY SSF103473 MFS general substrate transporter
18 385 InterPro IPR036259 MFS transporter superfamily
192 211 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
167 189 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
247 269 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
130 140 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
270 275 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
112 134 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
85 105 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
335 355 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
19 41 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
85 107 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
141 163 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
238 248 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
360 382 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
356 360 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
324 334 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
58 78 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
18 385 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
18 385 InterPro IPR020846 Major facilitator superfamily domain
302 324 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
141 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 42 Phobius SIGNAL_PEPTIDE Signal peptide region
56 78 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
43 57 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3773
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.94
1 0.909
4 0.908