Protein profile

PA3787

hypothetical protein

Genome: NC_002516.2

Gene: PA3787 Structure source: Experimental + AlphaFold UniProt Q9HXK8
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Amino acids 282
Annotations 2
Features 20
PDB binders 0
Druggability 0.911

Overview

Basic information about this protein and its source genome.

Accession
PA3787
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3787
Status
annotated
Amino acids
282
Structure source
Experimental + AlphaFold
GO
GO:0046872 Binding to a metal ion. GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.911
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0046872 Binding to a metal ion.
  • GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
179 273 Pfam PF01551 Peptidase family M23
179 273 InterPro IPR016047 Peptidase M23
125 279 FunFam G3DSA:2.70.70.10:FF:000019 M23 family peptidase
4 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
180 264 CDD cd12797 M23_peptidase
85 277 SUPERFAMILY SSF51261 Duplicated hybrid motif
85 277 InterPro IPR011055 Duplicated hybrid motif
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
91 274 PANTHER PTHR21666 PEPTIDASE-RELATED
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
25 124 Gene3D G3DSA:2.60.40.1590 Peptidoglycan hydrolase domains
20 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
125 281 Gene3D G3DSA:2.70.70.10 Glucose Permease (Domain IIA)
125 281 InterPro IPR011055 Duplicated hybrid motif
24 282 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
32 105 Pfam PF18421 Peptidase family M23 N-terminal domain
32 105 InterPro IPR040487 Peptidase family M23, N-terminal
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2HSI
X-ray 1.90 Å A,B
100.0% 1-282
PDBe RCSB PDBj File
Viewing
AlphaFold PA3787
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.911

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.28 0.38